Intercellular adhesion molecule-4 and CD36 are implicated in the abnormal adhesiveness of sickle cell SAD mouse erythrocytes to endothelium.

Intercellular adhesion molecule-4 and CD36 are implicated in the abnormal adhesiveness of sickle cell SAD mouse erythrocytes to endothelium.

BACKGROUND
adhesiveness abnormal red blood cells to the endothelium has been involved in vaso-occlusive crisis of sickle cell disease. This study examines whether the SAD mouse model showed the same abnormality adhesion of red blood cells found in human sickle cell disease.


METHOD
The repertoire of adhesion molecules in murine erythrocytes and bEnd.3 microvascular endothelial cells was determined by flow cytometry using monoclonal antibodies or by Western blotting. Adhesion investigated under dynamic conditions and are measured at different shear stresses.


RESULTS
CD36, CD47 and adhesion molecules between blood type-4, but not Lutheran antigen / basal cell adhesion molecules, which are present in the adult mouse erythrocytes. alpha (4) beta (1) is expressed on the SAD and the wild types of reticulocytes. bEnd.3 endothelial cells express alpha (v) beta (3), alpha (4) beta (1), CD47, vascular cell adhesion molecule-1, and the Lutheran blood group antigen molecules / basal cell adhesion, but not CD36.

Red blood cell adhesion SAD are: (i) 2 to 3 times higher than the wild-type red blood cells; (Ii) a further increase in platelet activating factor-activated endothelium; (Iii) are not stimulated by epinephrine; (Iv) inhibited after treating endothelial peptides bind to reproduce one of the sequences between mouse adhesion molecule-4, or with a mon-oclonal antibodies against murine alpha (v) integrin; and (v) inhibited after pretreatment red blood cells with monoclonal antibody anti-mouse CD36. Combination treatment with an adhesion molecule-4 peptides and anti-CD36 monoclonal antibody remove excess red blood cell adhesion SAD. Phosphorylation state of adhesion between the molecules-4 and CD36 may not engage in over-the adhesiveness of erythrocytes SAD.


CONCLUSION
inter adhesion molecule-4 / alpha (v) beta (3) and CD36 / thrombospondin interaction may contribute to an abnormally high adhesion of red blood cells SAD. Mouse SAD is a valuable animal model to investigate the process of adhesion of sickle cell disease.

Intercellular adhesion molecule-4 and CD36 are implicated in the abnormal adhesiveness of sickle cell SAD mouse erythrocytes to endothelium.
Intercellular adhesion molecule-4 and CD36 are implicated in the abnormal adhesiveness of sickle cell SAD mouse erythrocytes to endothelium.

The globoside receptor triggers structural changes in the viral capsid B19 that facilitates virus internalization.

Globoside (Gb4Cer), Ku80 auto anti gene, and α 5 β1 integrin has been identified as a cell receptors / coreceptors for human parvovirus B19 (B19V), but their role and mechanisms of interaction with the virus largely unknown. In UT7 / Epo cells, expression Gb4Cer and CD49e ( integrin alpha – 5 ) is high, but not significant Ku80 expression. B19V colocalized with Gb4Cer and, to a lesser extent, with CD49e. However, only anti -Gb4Cer anti the body can interfere with the attachment of the virus. Only a small portion of the cell-bound viruses are internalized, while the majority became detached from the receptor. When added to cells that are not infected, the virus receptor-detached shows superior binding capacity of cells and infectivity.

B19V attachment to the cell triggers a conformational change in the capsid leads to the accessibility of the N terminus of VP1 (VP1u) to anti body, which is maintained in a separate virus-receptor. VP1u be equally accessible to anti the following entities B19V particle incubation with increasing concentrations of purified Gb4Cer. Exposure VP1u receptor-mediated internalization is crucial for the virus, because less VP1 capsids can bind cells but not internalized.

Bovine Leukemia Inhibitory Factor (LIF) ELISA Kit

RD-LIF-b-48Tests 48 Tests
EUR 555

Bovine Leukemia Inhibitory Factor (LIF) ELISA Kit

RD-LIF-b-96Tests 96 Tests
EUR 771

Canine Leukemia Inhibitory Factor (LIF) ELISA Kit

RD-LIF-c-48Tests 48 Tests
EUR 533

Canine Leukemia Inhibitory Factor (LIF) ELISA Kit

RD-LIF-c-96Tests 96 Tests
EUR 740

Human Leukemia Inhibitory Factor (LIF) ELISA Kit

RD-LIF-Hu-48Tests 48 Tests
EUR 367

Human Leukemia Inhibitory Factor (LIF) ELISA Kit

RD-LIF-Hu-96Tests 96 Tests
EUR 502

Porcine Leukemia Inhibitory Factor (LIF) ELISA Kit

RD-LIF-p-48Tests 48 Tests
EUR 555

Porcine Leukemia Inhibitory Factor (LIF) ELISA Kit

RD-LIF-p-96Tests 96 Tests
EUR 771

Rat Leukemia Inhibitory Factor (LIF) ELISA Kit

RD-LIF-Ra-48Tests 48 Tests
EUR 511

Rat Leukemia Inhibitory Factor (LIF) ELISA Kit

RD-LIF-Ra-96Tests 96 Tests
EUR 709

Bovine Leukemia Inhibitory Factor (LIF) ELISA Kit

DLR-LIF-b-48T 48T
EUR 547
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Leukemia Inhibitory Factor (LIF) in samples from serum, plasma, tissue homogenates or other biological fluids.

Bovine Leukemia Inhibitory Factor (LIF) ELISA Kit

DLR-LIF-b-96T 96T
EUR 715
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Leukemia Inhibitory Factor (LIF) in samples from serum, plasma, tissue homogenates or other biological fluids.

Canine Leukemia Inhibitory Factor (LIF) ELISA Kit

DLR-LIF-c-48T 48T
EUR 527
Description: A sandwich quantitative ELISA assay kit for detection of Canine Leukemia Inhibitory Factor (LIF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Canine Leukemia Inhibitory Factor (LIF) ELISA Kit

DLR-LIF-c-96T 96T
EUR 688
Description: A sandwich quantitative ELISA assay kit for detection of Canine Leukemia Inhibitory Factor (LIF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Leukemia Inhibitory Factor (LIF) ELISA Kit

DLR-LIF-Hu-48T 48T
EUR 380
Description: A sandwich quantitative ELISA assay kit for detection of Human Leukemia Inhibitory Factor (LIF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Leukemia Inhibitory Factor (LIF) ELISA Kit

DLR-LIF-Hu-96T 96T
EUR 485
Description: A sandwich quantitative ELISA assay kit for detection of Human Leukemia Inhibitory Factor (LIF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Porcine Leukemia Inhibitory Factor (LIF) ELISA Kit

DLR-LIF-p-48T 48T
EUR 547
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Leukemia Inhibitory Factor (LIF) in samples from serum, plasma, tissue homogenates or other biological fluids.

Porcine Leukemia Inhibitory Factor (LIF) ELISA Kit

DLR-LIF-p-96T 96T
EUR 715
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Leukemia Inhibitory Factor (LIF) in samples from serum, plasma, tissue homogenates or other biological fluids.

Rat Leukemia Inhibitory Factor (LIF) ELISA Kit

DLR-LIF-Ra-48T 48T
EUR 508
Description: A sandwich quantitative ELISA assay kit for detection of Rat Leukemia Inhibitory Factor (LIF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Leukemia Inhibitory Factor (LIF) ELISA Kit

DLR-LIF-Ra-96T 96T
EUR 661
Description: A sandwich quantitative ELISA assay kit for detection of Rat Leukemia Inhibitory Factor (LIF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Bovine Leukemia Inhibitory Factor (LIF) ELISA Kit

RDR-LIF-b-48Tests 48 Tests
EUR 580

Bovine Leukemia Inhibitory Factor (LIF) ELISA Kit

RDR-LIF-b-96Tests 96 Tests
EUR 807

Canine Leukemia Inhibitory Factor (LIF) ELISA Kit

RDR-LIF-c-48Tests 48 Tests
EUR 557

Canine Leukemia Inhibitory Factor (LIF) ELISA Kit

RDR-LIF-c-96Tests 96 Tests
EUR 774

Human Leukemia Inhibitory Factor (LIF) ELISA Kit

RDR-LIF-Hu-48Tests 48 Tests
EUR 383

Human Leukemia Inhibitory Factor (LIF) ELISA Kit

RDR-LIF-Hu-96Tests 96 Tests
EUR 525

Porcine Leukemia Inhibitory Factor (LIF) ELISA Kit

RDR-LIF-p-48Tests 48 Tests
EUR 580

Porcine Leukemia Inhibitory Factor (LIF) ELISA Kit

RDR-LIF-p-96Tests 96 Tests
EUR 807

Rat Leukemia Inhibitory Factor (LIF) ELISA Kit

RDR-LIF-Ra-48Tests 48 Tests
EUR 534

Rat Leukemia Inhibitory Factor (LIF) ELISA Kit

RDR-LIF-Ra-96Tests 96 Tests
EUR 742

Anti-LIF Antibody

PA1562 100ug/vial
EUR 294

Anti-LIF Antibody

PB9036 100ug/vial
EUR 334

Anti-LIF antibody

STJ29846 100 µl
EUR 277
Description: The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Anti-LIF Antibody

A01400 100ug/vial
EUR 294

Anti-LIF antibody

STJ96472 200 µl
EUR 197
Description: Rabbit polyclonal to LIF.

Anti-LIF antibody

STJ73631 100 µg
EUR 359

anti- LIF antibody

FNab09804 100µg
EUR 548.75
Description: Antibody raised against LIF

anti- LIF antibody

LSMab09804 100 ug
EUR 386

LIF, Mouse

HY-P7084 50ug
EUR 533

LIF, mouse

MO16102 100 ug
EUR 675

Anti-LIF (aa28-39) antibody

STJ72919 100 µg
EUR 359

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 280

Polyclonal Goat anti-GST μ-form

GST-ANTI-2 50 uL
EUR 280

Polyclonal Goat anti-GST p-form

GST-ANTI-3 50 uL
EUR 280

Recombinant Mouse LIF Protein

R01400-1 100ug/vial
EUR 294

Mouse LIF ELISA Kit

EML0014 96Tests
EUR 521

Mouse LIF shRNA Plasmid

20-abx971321
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg

LIF Antibody

1-CSB-PA198481
  • EUR 317.00
  • EUR 244.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against LIF. Recognizes LIF from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:10000, IHC:1:25-1:100

LIF Antibody

1-CSB-PA012928ESR2HU
  • EUR 222.00
  • EUR 335.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against LIF. Recognizes LIF from Human. This antibody is Unconjugated. Tested in the following application: ELISA

LIF Antibody

1-CSB-PA004761
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against LIF. Recognizes LIF from Human. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/20000

LIF, Human

HY-P7049 10ug
EUR 1600

LIF, human

MO16101 100 ug
EUR 688

LIF Antibody

36950-100ul 100ul
EUR 252

LIF Antibody

25283-100ul 100ul
EUR 390

LIF siRNA

20-abx922546
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

LIF siRNA

20-abx922547
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

rHu LIF

AK9977-0005 5µg Ask for price

rHu LIF

AK9977-0025 25µg Ask for price

rHu LIF

AK9977-0100 100µg Ask for price

rHu LIF

AK9977-1000 1mg Ask for price

LIF Peptide

6245P 0.05 mg
EUR 164.75
Description: (IN) LIF peptide

LIF Peptide

43-200P 0.1 mg
EUR 338

LIF antibody

70R-12299 100 ug
EUR 403
Description: Rabbit polyclonal LIF antibody

LIF antibody

70R-14100 100 ug
EUR 322
Description: Affinity purified Rabbit polyclonal LIF antibody

LIF antibody

70R-6230 50 ug
EUR 467
Description: Rabbit polyclonal LIF antibody

LIF antibody

70R-51295 100 ul
EUR 244
Description: Purified Polyclonal LIF antibody

LIF protein

30R-2771 10 ug
EUR 369
Description: Purified recombinant Human LIF protein

LIF protein

30R-2772 10 ug
EUR 489
Description: Purified recombinant Mouse LIF protein

LIF Antibody

6245-002mg 0.02 mg
EUR 171.82
Description: LIF Antibody: LIF is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. LIF was initially recognized by its ability to induce terminal differentiation of myeloid leukemic cells. It is a member of the IL-6 cytokine superfamily and can be highly glycosylated. LIF signaling is transduced through the LIF-R/gp130 receptor complex, leading to the phosphorylation and activation of the JAK/STAT pathway. Recent evidence shows that LIF inhibits cardiomyogenesis in embryonic stem cells via STAT3 activation.

LIF Antibody

6245-01mg 0.1 mg
EUR 436.42
Description: LIF Antibody: LIF is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. LIF was initially recognized by its ability to induce terminal differentiation of myeloid leukemic cells. It is a member of the IL-6 cytokine superfamily and can be highly glycosylated. LIF signaling is transduced through the LIF-R/gp130 receptor complex, leading to the phosphorylation and activation of the JAK/STAT pathway. Recent evidence shows that LIF inhibits cardiomyogenesis in embryonic stem cells via STAT3 activation.

LIF antibody

PAab09804 100 ug
EUR 386

LIF Antibody

5216-100
EUR 316

LIF Antibody

5216-30T
EUR 146

LIF Antibody

DF13730 100ul
EUR 350

Mouse LIF PicoKine ELISA Kit

EK0580 96 wells
EUR 425
Description: For quantitative detection of mouse LIF in cell culture supernates, serum and plasma (heparin, EDTA).

Leukemia Inhibitory Factor (LIF), mouse

PR16102 5 ug
EUR 435

LIF, Mouse Recombinant , 1MIU/ml

L4500-001 1ml
EUR 339

LIF, Mouse Recombinant , 1MIU/ml

L4500-005 5x1ml
EUR 1193

LIF, Mouse Recombinant , 10MIU/ml

L4501-001 1ml
EUR 1454

LIF ELISA Kit (Mouse) (OKEH04045)

OKEH04045 96 Wells
EUR 544
Description: Description of target: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.039 ng/mL

LIF ELISA Kit (Mouse) (OKBB00760)

OKBB00760 96 Wells
EUR 505
Description: Description of target: Leukemia inhibitory factor, or LIF, is an interleukin 6 class cytokine that affects cell growth by inhibiting differentiation. When LIF levels drop, the cells differentiate. The LIF was mapped gene to 22q11-q12.2 by Southern analysis of a series of mouse/human somatic cell hybrids and by in situ hybridization to the chromosomes of 2 normal males and some individuals with chromosomal rearrangements. The gene maps between the Philadelphia translocation BCR1 and the breakpoint of the translocation in cell line GM2324 at 22q12.2. LIF derives its name from its ability to induce the terminal differentiation of myeloid leukemic cells, thus preventing their continued growth. Other properties attributed to the cytokine include: the growth promotion and cell differentiation of different types of target cells, influence on bone metabolism, cachexia, neural development, embryogenesis and inflammation.;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: <10pg/ml

ELISA kit for Mouse LIF

EK5250 96 tests
EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse LIF in samples from serum, plasma, tissue homogenates and other biological fluids.

Lif ORF Vector (Mouse) (pORF)

ORF049145 1.0 ug DNA
EUR 506

Lif ORF Vector (Mouse) (pORF)

ORF049146 1.0 ug DNA
EUR 506

Human CellExp? LIF, mouse recombinant

7268-10
EUR 370

LIF Polyclonal Antibody

ES3837-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against LIF from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

LIF Polyclonal Antibody

ES3837-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against LIF from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Polyclonal LIF Antibody

APR00279G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human LIF . This antibody is tested and proven to work in the following applications:

Polyclonal LIF Antibody

APR06696G 0.1 mg
EUR 659
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human LIF . This antibody is tested and proven to work in the following applications:

LIF Polyclonal Antibody

ABP52838-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of LIF from Human. This LIF antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human LIF

LIF Polyclonal Antibody

ABP52838-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of LIF from Human. This LIF antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human LIF

LIF Polyclonal Antibody

ABP52838-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of LIF from Human. This LIF antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human LIF

LIF Blocking Peptide

20-abx064170
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg

LIF Rabbit pAb

A1288-100ul 100 ul
EUR 308

LIF Rabbit pAb

A1288-200ul 200 ul
EUR 459

LIF Rabbit pAb

A1288-20ul 20 ul
EUR 183

LIF Rabbit pAb

A1288-50ul 50 ul
EUR 223

LIF Conjugated Antibody

C36950 100ul
EUR 397

LIF Polyclonal Antibody

41551-100ul 100ul
EUR 252

LIF Polyclonal Antibody

41551-50ul 50ul
EUR 187

LIF Blocking Peptide

33R-4712 100 ug
EUR 180
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of LIF antibody, catalog no. 70R-6230

LIF Recombinant Protein

40-682 5 ug
EUR 259.25
Description: LIF is a pleiotrophic factor produced by multiple cell types, including T cells, myelomonocytic lineages, fibroblasts, liver, heart and melanoma. LIF promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation. Other activities include the stimulation of acute phase protein synthesis by hepatocytes, stimulation of differentiation of cholinergic nerves, and suppression of adipogenesis by inhibiting the lipoprotein lipase in adipocytes. While human LIF is active on mouse cells and is widely used in the maintenance of murine ESC to prevent spontaneous differentiation, mouse LIF is not active on human cells due to its inability to bind to the human LIF receptor. Recombinant Murine LIF is a 19.9 kDa protein containing 180 amino acids residues, including three disulfide bonds.

LIF Recombinant Protein

40-684 5 ug
EUR 259.25
Description: LIF is a pleiotrophic factor produced by multiple cell types, including T cells, myelomonocytic lineages, fibroblasts, liver, heart and melanoma. LIF promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation. Other activities include the stimulation of acute phase protein synthesis by hepatocytes, stimulation of differentiation of cholinergic nerves, and suppression of adipogenesis by inhibiting the lipoprotein lipase in adipocytes. While human LIF is active on mouse cells and is widely used in the maintenance of murine ESC to prevent spontaneous differentiation, mouse LIF is not active on human cells due to its inability to bind to the human LIF receptor. Recombinant Human LIF is a 19.7 kDa protein containing 180 amino acid residues, including three disulfide bonds.

LIF Recombinant Protein

97-011 0.02 mg
EUR 390.5
Description: Leukemia inhibitory factor, or LIF, an interleukin 6 class cytokine, is a protein in cells that affects cell growth and development.Leukemia Inhibitory Factor has several functions such as cholinergic neuron differentiation, control of stem cell pluripotency, bone & fat metabolism, mitogenesis of factor dependent cell lines & promotion of megakaryocyte production in vivo. Removal of LIF pushes stem cells toward differentiation, but they retain their proliferative potential or pluripotency. Therefore LIF is used in mouse embryonic stem cell culture. It is necessary to maintain the stem cells in an undifferentiated state, however genetic manipulation of embryonic stem cells allows for LIF independent growth, notably overexpression of the gene Nanog. LIF is not required for culture of human embryonic stem cells.

LIF, human recombinant

4923-10
EUR 305

LIF, human recombinant

4923-1000
EUR 5705

LIF, human recombinant

4923-50
EUR 664

LIF, murine recombinant

4924-10
EUR 370

LIF, murine recombinant

4924-1000
EUR 6836

LIF Recombinant Protein

90-277 10 ug
EUR 338
Description: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities also include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation and the stimulation of acute-phase protein synthesis in hepatocytes. LIF activates JAK & STAT signaling in human embryonic stem (ES) cells, but this pathway does not maintain pluripotency in these cells, which instead rely on FGF2-mediated ERK signaling. By contrast, mouse ES cells can be maintained by LIF-mediated JAK & STAT signaling. LIF binds to a high affinity heterodimeric receptor complex consisting of two proteins: LIF-R alpha that binds LIF with low affinity and the 130kDa (gp130) subunit that by itself does not bind LIF, but is required for high affinity binding of LIF.

LIF Recombinant Protein

91-014 0.05 mg
EUR 542.75
Description: Leukemia Inhibitory Factor (LIF) is a lymphoid factor that promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation. LIF has a number of other activities including cholinergic neuron differentiation, control of stem cell pluripotency, bone and fat metabolism, mitogenesis of certain factor dependent cell lines and promotion of megakaryocyte production in vivo. Human and murine mature LIF exhibit a 78% sequence identity at the amino acid level. Human LIF is equally active on human and mouse cells. Murine LIF is approximately 1000 fold less active on human cells than human LIF.

LIF Recombinant Protein

91-575 0.05 mg
EUR 490.25
Description: Mouse Leukemia inhibitory factor(lif)is a secreted protein which belongs to the LIF/OSM family.LIF has been implicated in a many physiological processes including development, hematopoiesis, bone metabolism, and inflammation. it has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.

LIF, Leukemia inhibitory factor, murine (mouse)

RC234-18 5ug
EUR 104.38

Mouse Leukemia Inhibitory Factor (LIF) Protein

20-abx067761
  • EUR 662.00
  • EUR 272.00
  • EUR 2012.00
  • EUR 787.00
  • EUR 481.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Leukemia Inhibitory Factor (LIF) Protein

abx262959-1mg 1 mg
EUR 3168

Mouse Leukemia Inhibitory Factor (LIF) Protein

abx262959-3x10g 3x10 µg
EUR 328

Mouse Leukemia Inhibitory Factor (LIF) Protein

abx262959-3x2g 3x2 µg
EUR 230

Recombinant Mouse Leukemia Inhibitory Factor/lIF

C690-10ug 10ug
EUR 146
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

Recombinant Mouse Leukemia Inhibitory Factor/lIF

C690-1mg 1mg
EUR 2283
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

Recombinant Mouse Leukemia Inhibitory Factor/lIF

C690-500ug 500ug
EUR 1613
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

Recombinant Mouse Leukemia Inhibitory Factor/lIF

C690-50ug 50ug
EUR 303
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

Lif sgRNA CRISPR Lentivector set (Mouse)

K3872501 3 x 1.0 ug
EUR 339

Nori® Mouse LIF ELISA Kit

GR117058 96-well
EUR 461

Recombinant Human LIF Protein

RP00089 10 μg
EUR 174

Sheep LIF ELISA Kit

ESL0014 96Tests
EUR 521

Recombinant Human LIF Protein

PROTP15018-5 25ug
EUR 317
Description: LIF is a pleiotrophic factor produced by multiple cell types including T cells, myelomoncytic lineages, fibroblasts, liver, heart and melanoma. LIF promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation. Other activities include the stimulation of acute phase protein synthesis by hepatocytes, stimulation of differentiation of cholinergic nerves, and suppression of adipogenesis by inhibiting the lipoprotein lipase in adipocytes. While human LIF is active on mouse cells and is widely used in the maintenance of murine ESC to prevent spontaneous differentiation, mouse LIF is not active on human cells due to its inability to bind to the human LIF receptor. Recombinant human LIF is a 19.6 kDa protein containing 180 amino acids residues including three disulfide bonds.

LIF/Leukemia inhibitory factor

E21-017 10ug
EUR 343

LIF/Leukemia inhibitory factor

E21-690 10ug
EUR 343

Anserini LIF ELISA Kit

EAL0014 96Tests
EUR 521

Rat LIF ELISA Kit

ERL0014 96Tests
EUR 521

Rabbit LIF ELISA Kit

ERTL0014 96Tests
EUR 521

Monkey LIF ELISA Kit

EMKL0014 96Tests
EUR 521

Porcine LIF ELISA Kit

EPL0014 96Tests
EUR 521

Human LIF ELISA Kit

EHL0014 96Tests
EUR 521

Chicken LIF ELISA Kit

ECKL0014 96Tests
EUR 521

Canine LIF ELISA Kit

ECL0014 96Tests
EUR 521

Bovine LIF ELISA Kit

EBL0014 96Tests
EUR 521

Goat LIF ELISA Kit

EGTL0014 96Tests
EUR 521

Polyclonal LIF Antibody (Internal)

APR02876G 0.05mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human LIF (Internal). This antibody is tested and proven to work in the following applications:

Polyclonal LIF Antibody (Center)

APR05828G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human LIF (Center). This antibody is tested and proven to work in the following applications:

Human LIF shRNA Plasmid

20-abx952690
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg

Human LIF ELISA Kit

ELA-E0085h 96 Tests
EUR 824

LIF ELISA KIT|Human

EF000330 96 Tests
EUR 689

Human LIF ELISA kit

55R-2054 96 tests
EUR 712
Description: ELISA Kit for detection of LIF in the research laboratory

Human LIF ELISA kit

55R-IB49639 96 wells
EUR 1178
Description: ELISA kit for the detection of LIF in the research laboratory

Mouse Leukemia inhibitory factor, LIF ELISA kit

CSB-E04652m-24T 1 plate of 24 wells
EUR 165
Description: Quantitativesandwich ELISA kit for measuring Mouse Leukemia inhibitory factor, LIF in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse Leukemia inhibitory factor, LIF ELISA kit

1-CSB-E04652m
  • EUR 946.00
  • EUR 5782.00
  • EUR 3060.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Mouse Leukemia inhibitory factor, LIF in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Leukemia Inhibitory Factor (LIF) Polyclonal Antibody (Mouse)

4-PAA085Mu01
  • EUR 236.00
  • EUR 2338.00
  • EUR 586.00
  • EUR 294.00
  • EUR 209.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Leukemia Inhibitory Factor (LIF)

Recombinant Mouse LIF/Leukemia inhibitory factor Protein

RP00544 10 μg
EUR 174

Mouse Leukemia inhibitory factor(LIF)ELISA Kit  

GA-E0658MS-48T 48T
EUR 336

Mouse Leukemia inhibitory factor(LIF)ELISA Kit  

GA-E0658MS-96T 96T
EUR 534

LIF Leukemia Inhibitory Factor Mouse Recombinant Protein

PROTP09056 Regular: 25ug
EUR 317
Description: Leukemia Inhibitory Factor (LIF) Murine Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 181 amino acids and having a molecular mass of 20 kDa. ;The Leukemia Inhibitory Factor (LIF) is purified by proprietary chromatographic techniques.

Mouse Lif/ Leukemia inhibitory factor ELISA Kit

E1656Mo 1 Kit
EUR 546

ISOKine-Leukemia Inhibitory Factor (LIF), mouse-NEW

PR80000 50 ug
EUR 376

Mouse Leukemia Inhibitory Factor (LIF) ELISA Kit

abx574566-96tests 96 tests
EUR 754

Mouse Leukemia Inhibitory Factor (LIF) Protein (Active)

20-abx655747
  • EUR 857.00
  • EUR 314.00
  • EUR 2750.00
  • EUR 1024.00
  • EUR 592.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Leukemia Inhibitory Factor (LIF) CLIA Kit

abx195395-96tests 96 tests
EUR 825

Mouse Leukemia Inhibitory Factor (LIF) ELISA Kit

abx254611-96tests 96 tests
EUR 754

Mouse leukemia inhibitory factor(LIF)ELISA Kit

QY-E20907 96T
EUR 361

Mouse Lif(Leukemia inhibitory factor) ELISA Kit

EM0237 96T
EUR 567.6
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 46.9pg/ml

Mouse Leukemia inhibitory factor,LIF ELISA kit

CN-02441M1 96T
EUR 467

Mouse Leukemia inhibitory factor,LIF ELISA kit

CN-02441M2 48T
EUR 316

Lif sgRNA CRISPR Lentivector (Mouse) (Target 1)

K3872502 1.0 ug DNA
EUR 154

Lif sgRNA CRISPR Lentivector (Mouse) (Target 2)

K3872503 1.0 ug DNA
EUR 154

Lif sgRNA CRISPR Lentivector (Mouse) (Target 3)

K3872504 1.0 ug DNA
EUR 154

Recombinant Mouse LIF Protein, Untagged, E.coli-100ug

QP4235-100ug 100ug
EUR 608

Recombinant Mouse LIF Protein, Untagged, E.coli-1mg

QP4235-1mg 1mg
EUR 2658

Recombinant Mouse LIF Protein, Untagged, E.coli-20ug

QP4235-20ug 20ug
EUR 237

Recombinant Mouse LIF Protein, Untagged, E.coli-500ug

QP4235-500ug 500ug
EUR 1660

Recombinant Mouse LIF Protein, Untagged, E.coli-5ug

QP4235-5ug 5ug
EUR 136

LIF Protein Vector (Mouse) (pPB-C-His)

PV196578 500 ng
EUR 603

LIF Protein Vector (Mouse) (pPB-N-His)

PV196579 500 ng
EUR 603

LIF Protein Vector (Mouse) (pPM-C-HA)

PV196580 500 ng
EUR 603

LIF Protein Vector (Mouse) (pPM-C-His)

PV196581 500 ng
EUR 603

LIF Protein Vector (Mouse) (pPB-C-His)

PV196582 500 ng
EUR 603

LIF Protein Vector (Mouse) (pPB-N-His)

PV196583 500 ng
EUR 603

LIF Protein Vector (Mouse) (pPM-C-HA)

PV196584 500 ng
EUR 603

LIF Protein Vector (Mouse) (pPM-C-His)

PV196585 500 ng
EUR 603

Leukemia Inhibitory Factor (LIF) Polyclonal Antibody (Mouse), APC

4-PAA085Mu01-APC
  • EUR 329.00
  • EUR 3041.00
  • EUR 854.00
  • EUR 416.00
  • EUR 212.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Leukemia Inhibitory Factor (LIF). This antibody is labeled with APC.

Leukemia Inhibitory Factor (LIF) Polyclonal Antibody (Mouse), Biotinylated

4-PAA085Mu01-Biotin
  • EUR 299.00
  • EUR 2288.00
  • EUR 684.00
  • EUR 363.00
  • EUR 214.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Leukemia Inhibitory Factor (LIF). This antibody is labeled with Biotin.

Leukemia Inhibitory Factor (LIF) Polyclonal Antibody (Mouse), Cy3

4-PAA085Mu01-Cy3
  • EUR 397.00
  • EUR 4013.00
  • EUR 1097.00
  • EUR 513.00
  • EUR 241.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Leukemia Inhibitory Factor (LIF). This antibody is labeled with Cy3.

Leukemia Inhibitory Factor (LIF) Polyclonal Antibody (Mouse), FITC

4-PAA085Mu01-FITC
  • EUR 283.00
  • EUR 2452.00
  • EUR 703.00
  • EUR 353.00
  • EUR 189.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Leukemia Inhibitory Factor (LIF). This antibody is labeled with FITC.

Leukemia Inhibitory Factor (LIF) Polyclonal Antibody (Mouse), HRP

4-PAA085Mu01-HRP
  • EUR 302.00
  • EUR 2652.00
  • EUR 756.00
  • EUR 377.00
  • EUR 200.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Leukemia Inhibitory Factor (LIF). This antibody is labeled with HRP.

Leukemia Inhibitory Factor (LIF) Polyclonal Antibody (Mouse), PE

4-PAA085Mu01-PE
  • EUR 283.00
  • EUR 2452.00
  • EUR 703.00
  • EUR 353.00
  • EUR 189.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Leukemia Inhibitory Factor (LIF). This antibody is labeled with PE.

ELISA kit for Mouse LIF (Leukemia Inhibitory Factor)

E-EL-M0040 1 plate of 96 wells
EUR 534
Description: A sandwich ELISA kit for quantitative measurement of Mouse LIF (Leukemia Inhibitory Factor) in samples from Serum, Plasma, Cell supernatant

In addition, a anti the body of the N terminus of VP1u disrupted virus internalization, but only if it is present during and after the attachment of the virus, which indicates the involvement of these regions in the binding events required for internalization.