Innovex FC Receptor

innovexbio universal fc receptor blocker

INTRODUCTION

Fc receptors (FcRs) are glycoproteins of approximate molecular weights of 50-70 kD. They’re extensively expressed
all via the immune cells. Fc receptors are present on leukocytes equal to monocytes, tissue macrophages, B cells,
granulocytes (eosinophils, basophils, neutrophils), NK cells and some T cells. Fc receptors are moreover present on mast cells, follicular dendritic cells, epithelial cells, endothelial cells, hepatocytes and langerhans cells amongst others. There are a variety of types of Fc receptors (FcR) which can be categorised based on the antibody that they acknowledge. There are individuals who have good affinity for the Fc space of monomeric IgG antibody and are known as Fc-Gamma receptors, individuals who bind to IgA antibody are known as Fc-alpha receptors and individuals who bind IgE antibody are known as Fc-epsilon receptors.

Non specific Fc receptors staining in assays equal to IHC, ICC, Immunofluorescence (IF) and motion cytometry might find yourself from the binding of the Fc space of the primary and/or secondary antibody or immunoglobulin isotypes to the Fc receptors of the cells. Eliminating Fc receptor staining is fascinating in IHC, ICC, IF and Circulation cytometry assays for the purpose of appropriate data evaluation.
For IHC, ICC, IF testing: The binding of the Fc space of main and/or secondary antibody and immunoglobulin
isotypes to the Fc receptors present on cells/tissues give rise to non-specific Fc receptor staining. Specimens rich in Fc receptors embrace spleen, lymphoid tissues, lymphomas, tonsil, lymph nodes, bone marrow, blood smears and liver. Others embrace tissues and cell preps meant for staining for CD markers; Immunoglobulins (Igs), Kappa and Lambda and tumor cell traces that specific Fc receptors. To steer clear of Fc receptor staining; tissue sections and cell preparations are incubated with Innovex Fc Blocker for a short interval earlier to utility of main antibody or immunoglobulin isotypes (See instruction a part of this data sheet).

 

innovexbio universal fc receptor blocker
innovexbio common fc receptor blocker

For Circulation cytometry assays: Fc receptors are present on leukocytes (white blood cells), many cell traces along with totally different
cell varieties in every human and animal cells/tissues. Fc receptors affords rise to non-specific Fc receptor-staining in motion
cytometry assays by binding of Fc space of antibodies and isotype controls to Fc receptors of the cells. Non-specific Fc receptors staining is perhaps eradicated by incubating cells with INNOVEX Fc Receptor Blocker for a variety of Circulation cytometry assays equal to CD phenotyping, leukemia typing and cell line analysis. (See instruction a part of this data sheet).

PRODUCT DESCRIPTION

Innovex Fc Receptor Blocker is a UNIVERSAL Fc Blocker related to blocking all types of Fc receptors equal to Fc-gamma receptors of kind I,II and III; Fc -epsilon receptors kind I and II; Fc –alpha receptors, Fcα/ µR and FcRn. Innovex Fc Blocker does NOT comprise antibodies, Immunoglobulins or immunoglobulin fragments. INNOVEX Fc Blocker is perhaps universally utilized to dam all types of Fc receptors in all-species along with human, mouse and all-animals This Widespread Fc Block may be utilized in a variety of Immunoassays equal to IHC, ICC, Immunofluorescence and Circulation cytometry. INNOVEX UNIVERSAL Fc BLOCK is acceptable for blocking Fc receptors in frozen and paraffin tissuesections and cyto preps of human and all-animal species. INNOVEX Fc Blocker can be usually used for eliminating background staining in thoughts cells/tissues.

 

Fc Receptor Blocker, 30ml

NB309-30 30 ml
EUR 609.6

Fc Receptor Blocker, 5ml

NB309-5S 5 ml
EUR 225.6

Universal Casein Diluent/Blocker

85R-108 250 ml
EUR 276
Description: Ready-to-use biotin free reagent applicable for blocking ELISA plates

Universal IHC Diluent/Blocker/Stabilizer

85R-1021 1 liter
EUR 830.4
Description: Universal Diluent/Blocker/Stabilizer for use in IHC

Azide Free Fc Receptor Blocker NEW

NB335-60 60 ml
EUR 1027.2

Enhanced Universal IHC Diluent/Blocker/Stabilizer

85R-1021E 100 ml
EUR 224.4
Description: Enhanced Universal Diluent/Blocker/Stabilizer for use in IHC

Fc Receptor Blocker; 4X Concentrate, 15ml NEW

NB309-4X-15 15 ml of 4X
EUR 930

Azide Free Fc Rreceptor Blocker

NB335 30 ml
EUR 651.6

Sheep IgG-Fc ELISA Kit, 96 tests, Quantitative

7615-Fc 1 kit
EUR 854.4

Horse IgG-Fc ELISA Kit, 96 tests, Quantitative

7715-Fc 1 kit
EUR 854.4

Dog IgG (Fc) fragment (isotype control, non-immune), purified

20016-FC 0.5 mg
EUR 300

Human IgG (Fc) fragment, purified

20007-1-FC 0.5 mg
EUR 249.6

Mouse IgG (Fc) fragment, purified

20008-1-FC 0.5 mg
EUR 300

Rabbit IgG (Fc) fragment, purified

20009-1-FC 0.5 mg
EUR 300

Goat IgG (Fc) fragment, purified

20011-1-FC 0.5 mg
EUR 300

Hen Blocker

CH23106 100 ml
EUR 434.4

Rat IgG (Fc) fragment, purified (isotype control)

20005-1-FC 0.5 mg
EUR 300

Goat IgG (fc)-Biotin conjugate (isotype control)

20011-Fc-B 100 ug
EUR 196.8

Goat IgG (fc)-FITC conjugate (isotype control)

20011-Fc-F 100 ug
EUR 196.8

Goat IgG (fc)-HRP conjugate (isotype control)

20011-Fc-HP 100 ug
EUR 196.8

Dog IgG (Fc) fragment (isotype control, non-immune), purified

20016-3-FC 0.5 mg
EUR 300

Dog IgG Fc-Biotin Conjugate (isotype control, non-immune), purified

20016-FC-B 0.1 mg
EUR 270

Leave a Comment

Your email address will not be published.