Amyloid

Amyloid Beta Protein

Biochem/physiol Actions

Amyloid β-protein is neurotrophic and neurotoxic in vivo and in vitro in human and rat neuronal cell cultures. β-Amyloid peptides (amino acids 1-42 and 1-43) are the foremost constituents of senile plaques and neurofibrillary tangles that occur throughout the hippocampus, neocortex, and amygdala of victims with Alzheimer′s sickness.
Amyloid β Protein Fragment 1-40 (Aβ40) varieties cation primarily based ion channels.

DESCRIPTION

Amino Acid Sequence

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val

Primary description

Amyloid β Protein Fragment 1-40 (Aβ40) is derived from the amyloid-β protein (Aβ), which is mapped to human chromosome 21q21.3. Aβ40 is predominantly present throughout the vascular amyloid deposits. Aβ40 accommodates of C-terminal membrane insertion space. It displays structural transition from random coil to a α-helical development in a water-micelle medium.

Utility

Amyloid β Protein Fragment 1-40 has been used:

  • throughout the temperature primarily based conformational analysis using Fourier rework infrared/differential scanning calorimetry (FT-IR/DSC) analysis
  • as a reference commonplace in sandwich-type enzyme immunoassay for quantifying amyloid A4 protein in cerebrospinal fluid of victims with head trauma
  • as a aspect of embryonic stem cell medium to inhibit amyloid deposition in fibroblasts
amyloid
amyloid

Reconstitution

For maximal natural train, dilute the stock in calcium-free PBS to 1 mg/ml and incubate at 37 °C for 4 days.

Totally different Notes

Lyophilized from 0.1% TFA in H2O

Abstract

Alzheimer’s sickness (AD) pathogenesis is broadly believed to be pushed by the manufacturing and deposition of the β-amyloid peptide (Aβ). For just a few years, investigators have been puzzled by the weak to nonexistent correlation between the amount of neuritic plaque pathology throughout the human thoughts and the diploma of scientific dementia. Present advances in our understanding of the occasion of amyloid pathology have helped treatment this thriller. Substantial proof now signifies that the solubility of Aβ, and the quantity of Aβ in quite a few swimming swimming pools, is also additional fastidiously related to sickness state. The composition of these swimming swimming pools of Aβ shows fully totally different populations of amyloid deposits, and has specific correlates with the scientific standing of the affected particular person. Imaging utilized sciences, along with new amyloid imaging brokers based mostly totally on the chemical development of histologic dyes, in the intervening time are making it doable to hint amyloid pathology along with sickness improvement throughout the residing affected particular person. Curiously, these approaches level out that the Aβ deposited in AD is totally totally different from that current in animal fashions. Mainly, deposited Aβ is additional merely cleared from the thoughts in animal fashions, and would not current the an identical bodily and biochemical traits as a result of the amyloid current in AD. This raises essential factors in regards to the occasion and testing of future therapeutic brokers.

Key phrases: Amyloid, β-Amyloid Precursor Protein, Aβ, oligomer, fibril

Beta Amyloid

MO22142 100 ul
EUR 522

Rat beta amyloid(beta-amyloid)ELISA Kit

YLA1575RA-48T 48T
EUR 465

Rat beta amyloid(beta-amyloid)ELISA Kit

YLA1575RA-96T 96T
EUR 600

Mouse beta amyloid(beta-amyloid)ELISA Kit

YLA1762MO-48T 48T
EUR 465

Mouse beta amyloid(beta-amyloid)ELISA Kit

YLA1762MO-96T 96T
EUR 600

beta Amyloid 40 protein

30R-3013 500 ug
EUR 392.4
Description: Purified recombinant beta Amyloid 40 protein

beta Amyloid 42 protein

30R-3014 500 ug
EUR 392.4
Description: Purified recombinant beta Amyloid 42 protein

beta Amyloid antibody

70R-AR020 100 ug
EUR 360
Description: Affinity purified Rabbit polyclonal beta Amyloid antibody

beta Amyloid antibody

70R-BR019 100 ug
EUR 360
Description: Affinity purified Rabbit polyclonal beta Amyloid antibody

Beta Amyloid antibody

70R-51450 100 ul
EUR 344.4
Description: Purified Polyclonal Beta Amyloid antibody

beta Amyloid antibody

70R-10624 1 ml
EUR 831.6
Description: Affinity purified Chicken polyclonal beta Amyloid antibody

beta Amyloid antibody

70R-12571 100 ul
EUR 548.4
Description: Affinity purified Rabbit polyclonal beta Amyloid antibody

beta Amyloid antibody

20R-AR011 250 ul
EUR 457.2
Description: Rabbit polyclonal beta Amyloid antibody

beta-Amyloid antibody

22965-100ul 100ul
EUR 468

beta Amyloid Antibody

35506-100ul 100ul
EUR 468

beta Amyloid antibody

10R-7917 100 ug
EUR 386.4
Description: Mouse monoclonal beta Amyloid antibody

beta Amyloid antibody

10R-A124a 50 ug
EUR 1213.2
Description: Mouse monoclonal beta Amyloid antibody

Amyloid beta Antibody

F49577-0.4ML 0.4 ml
EUR 379

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