Involvement of ROS-alpha v beta 3 integrin-FAK/Pyk2 in the inhibitory effect of melatonin on U251 glioma cell migration and invasion under hypoxia.

Involvement of ROS-alpha v beta 3 integrin-FAK/Pyk2 in the inhibitory effect of melatonin on U251 glioma cell migration and invasion under hypoxia.

BACKGROUND
Melatonin, which is well-known antioxidant, has been shown to have anti-invasive properties for glioma. However, little is known about the effects of melatonin on the migration and invasion of glioma cells under hypoxia, which is essential for the progress of the microenvironment of the tumor. In addition, the focus of adhesion kinase (FAK) and a proline-rich tyrosine kinase 2 (Pyk2) are closely associated with cell migration and invasion. Therefore, we investigated the possible role of this kinase and related signal in the regulation of the behavior of a human U251 glioma cells with melatonin under hypoxia.


METHOD
The ability of U251 cells migration and invasion of glioma determined by the wound healing and transwell in vitro assays. Production of intracellular reactive oxygen species (ROS) were measured using a fluorescent probe 6-carboxy-2 ‘, 7’-dichorodihydrofluorescein diacetate (DCFH-DA). experiment immunofluorescence and Western blotting analysis is used to detect the protein expression levels. Disturb small RNA (siRNA) was used to silence the expression of specific genes.


RESULTS
Pharmacological concentration (1 mM) of melatonin significantly inhibited the migration and invasion of human glioma U251 cells under hypoxia. The inhibitory effect of melatonin is accompanied by decreased phosphorylation of FAK and Pyk2, and decreased expression of alpha v beta 3 (αvβ3) integrin. Additionally, αvβ3 integrin inhibition by siRNA reduces phosphorylation of FAK / Pyk2 and shows anti-tumor effects are the same as melatonin, indicating the involvement of αvβ3 integrin- FAK / Pyk2 pathway in anti-migration and anti-invasive melatonin. It was also found that melatonin treatment decreased ROS levels in U251 glioma cells cultured under hypoxia. ROS inhibitor apocynin not only inhibit integrin αvβ3 expression and phosphorylation of FAK and Pyk2 level, but also suppresses the migration and invasive capacity U251 glioma cells under hypoxia.


CONCLUSION
These results suggest that melatonin exerts anti-migratory effect and anti-invasive glioma cells in response to hypoxia via ROS-αvβ3 integrin-FAK / Pyk2 signal path. This provides evidence that melatonin may be a potential therapeutic molecules targeting the hypoxic micro glioma.

Involvement of ROS-alpha v beta 3 integrin-FAK/Pyk2 in the inhibitory effect of melatonin on U251 glioma cell migration and invasion under hypoxia.
Involvement of ROS-alpha v beta 3 integrin-FAK/Pyk2 in the inhibitory effect of melatonin on U251 glioma cell migration and invasion under hypoxia.

Epithelial V-like antigen mediate the efficacy of anti-integrin alpha₄ treatment in a mouse model of multiple sclerosis.

Natalizumab inhibit the transmigration of activated T lymphocytes into the brain and is efficacious in multiple sclerosis (MS). However, from the perspective of pharmacogenomics, efficacy and safety in certain patients remains unclear. Here our aim is to analyze the effects of epithelial V-like antigen (EVA) on the anti-alpha₄ integrin (VLA4) efficacy in a mouse model of MS, experimental autoimmune encephalomyelitis (EAE). EVA has previously been characterized in human CD4 + T lymphocytes, mouse thymus development, and epithelial cells of the choroid plexus.

Further analysis here showed expression in B lymphocytes, and increase lymphocyte EVA⁺ after immunization. The following active induction of EAE model MOG³⁵⁻⁵⁵ active immunization, EVA deficient mice developed EAE injury and white matter tissue is more severe than the wild type control. This severe EAE phenotype did not respond to anti-VLA4 treatment. In both the control condition and the anti-VLA4 antibodies, these mice show persistent CNS invasion mature B lymphocytes (CD19⁺, CD21⁺, sIgG⁺), increased serum levels of autoantibodies, and appendages broad and IgG deposition in the lesion containing CD5⁺IgG⁺ cells.

IL-6, Interleukin-6, human

RC212-17 5ug
EUR 125.26

IL-17, Human

HY-P7036 10ug
EUR 253.2

IL-17

MO15110 500 ug
EUR 1092

IL-17

EF014060 96 Tests
EUR 826.8

IL-17

E5-00007 1mg
EUR 1152

IL-17

PR27113 5 ug
EUR 229.2

Anti-IL-17 alpha antibody

STJ93683 200 µl
EUR 236.4
Description: Rabbit polyclonal to IL-17Ralpha.

IL-17/IL-17A

E21-021 10ug
EUR 411.6

Recombinant Human IL-17

SJB09-03 25µg/vial
EUR 307.2

IL-6, Interleukin-6, rat

RC252-17 2ug
EUR 125.26

Interleukin 17 (IL-17) Antibody

abx234224-100ug 100 ug
EUR 610.8

Interleukin 17 (IL-17) Antibody

abx234225-100ug 100 ug
EUR 577.2

Bovine Interleukin 17(IL-17)

QY-E60069 96T
EUR 511.2

IL-17 Antibody

5176-100
EUR 405.6

IL-17 Antibody

4877-002mg 0.02 mg
EUR 206.18
Description: IL-17 Antibody: Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines produced by activated T cells and is thought to have a major role in the initiation and perpetuation of rheumatoid arthritis. IL-17 regulates the activities of NF-κB and mitogen-activated protein kinases such as ERK and JNK. In addition, IL-17 stimulates the expression of IL-6 and cyclooxygenase-2 and enhances the production of nitric oxide. IL-17-producing T helper cells (TH-17 cells) have been the subject of much attention due to the importance of IL-17 in the pathogenesis of autoimmune inflammation. Because of its role in autoimmune diseases, it is thought that targeting the production and action of IL-17 would be beneficial therapeutically in these diseases.

IL-17 Antibody

4877-01mg 0.1 mg
EUR 523.7
Description: IL-17 Antibody: Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines produced by activated T cells and is thought to have a major role in the initiation and perpetuation of rheumatoid arthritis. IL-17 regulates the activities of NF-κB and mitogen-activated protein kinases such as ERK and JNK. In addition, IL-17 stimulates the expression of IL-6 and cyclooxygenase-2 and enhances the production of nitric oxide. IL-17-producing T helper cells (TH-17 cells) have been the subject of much attention due to the importance of IL-17 in the pathogenesis of autoimmune inflammation. Because of its role in autoimmune diseases, it is thought that targeting the production and action of IL-17 would be beneficial therapeutically in these diseases.

IL-17 Peptide

4877P 0.05 mg
EUR 197.7
Description: (NT) IL-17 peptide

IL-17 Antibody

4887-002mg 0.02 mg
EUR 206.18
Description: IL-17 Antibody: Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines produced by activated T cells and is thought to have a major role in the initiation and perpetuation of rheumatoid arthritis. IL-17 regulates the activities of NF-κB and mitogen-activated protein kinases such as ERK and JNK. In addition, IL-17 stimulates the expression of IL-6 and cyclooxygenase-2 and enhances the production of nitric oxide. IL-17-producing T helper cells (TH-17 cells) have been the subject of much attention due to the importance of IL-17 in the pathogenesis of autoimmune inflammation. Because of its role in autoimmune diseases, it is thought that targeting the production and action of IL-17 would be beneficial therapeutically in these diseases.

IL-17 Antibody

4887-01mg 0.1 mg
EUR 523.7
Description: IL-17 Antibody: Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines produced by activated T cells and is thought to have a major role in the initiation and perpetuation of rheumatoid arthritis. IL-17 regulates the activities of NF-κB and mitogen-activated protein kinases such as ERK and JNK. In addition, IL-17 stimulates the expression of IL-6 and cyclooxygenase-2 and enhances the production of nitric oxide. IL-17-producing T helper cells (TH-17 cells) have been the subject of much attention due to the importance of IL-17 in the pathogenesis of autoimmune inflammation. Because of its role in autoimmune diseases, it is thought that targeting the production and action of IL-17 would be beneficial therapeutically in these diseases.

IL-17 Peptide

4887P 0.05 mg
EUR 197.7
Description: (IN) IL-17 peptide

IL-17 Antibody

24784-100ul 100ul
EUR 468

IL-17 Antibody

24789-100ul 100ul
EUR 468

IL-17 Antibody

R35097-100UG 100 ug
EUR 399

IL-17 Antibody

R36188-100UG 100 ug
EUR 399

IL-17 Antibody

F42568-0.4ML 0.4 ml
EUR 379

Human Interleukin 17 (IL-17) CLIA Kit

abx195860-96tests 96 tests
EUR 990

Human Interleukin 17,IL-17 ELISA Kit

201-12-0143 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Interleukin 17,IL-17 ELISA Kit

CN-03335H1 96T
EUR 520.8

Human Interleukin 17,IL-17 ELISA Kit

CN-03335H2 48T
EUR 340.8

Human Interleukin 17(IL-17)ELISA Kit

GA-E0081HM-48T 48T
EUR 346.8

Human Interleukin 17(IL-17)ELISA Kit

GA-E0081HM-96T 96T
EUR 559.2

IL-17 Interleukin-17 Human Recombinant Protein

PROTQ16552-1 Regular: 25ug
EUR 380.4
Description: Interleukin-17A Human Recombinant produced in E.Coli is a homodimeric, non-glycosylated polypeptide chain containing a total of 264 amino acids (2 chains of 132 aa) and having a molecular mass of 31kDa.  ;The IL-17 is purified by proprietary chromatographic techniques.

Human Interleukin 17(IL-17)ELISA Kit

QY-E04323 96T
EUR 433.2

IL-6, Interleukin-6, murine (mouse)

RC232-17 2ug
EUR 125.26

Recombinant Human IL-17 (IL-17A) Protein

PROTQ16552-4 25ug
EUR 380.4
Description: The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 136 amino acid chains, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules.  Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles.  The six known members of this family, IL-17A through IL-17F, are secreted as homodimers.  IL-17A exhibits cross-species bioactivity between human and murine cells.  Recombinant human IL-17A is a 31.3 kDa disulfide-linked homodimer of two 137 amino acid polypeptide chains.

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 418.8

IL-6, Interleukin-6, monkey (rhesus macaque)

RC222-17 2ug
EUR 125.26

IL-17 ELISA KIT|Human

EF006939 96 Tests
EUR 826.8

human IL-17, His tag

E410A10-100 100μg
EUR 1152

IL-17 (Human) ELISA Kit

E4628-100
EUR 874.8

Human IL-17 ELISA kit

LF-EK50201 1×96T
EUR 777.6

Human Interleukin 17 (IL-17) Detection Assay Kit

6808 1 kit
EUR 580.26
Description: Human Interleukin 17 (IL-17) Detection Assay Kit

CLIA kit for Human IL-17 (Interleukin 17)

E-CL-H0104 1 plate of 96 wells
EUR 700.8
Description: A sandwich CLIA kit for quantitative measurement of Human IL-17 (Interleukin 17) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human IL-17 (Interleukin 17)

E-EL-H0105 1 plate of 96 wells
EUR 452.4
Description: A sandwich ELISA kit for quantitative measurement of Human IL-17 (Interleukin 17) in samples from Serum, Plasma, Cell supernatant

IL-17 Interleukin-17 Human Recombinant Protein, HEK

PROTQ16552 Regular: 10ug
EUR 380.4
Description: IL-17 Human Recombinant produced in HEK cells is a glycosylated homodimer, having a molecular weight range of 30-35kDa due to glycosylation.;The IL-17 is purified by proprietary chromatographic techniques.

17-Hydroxyprogesterone (17-OHP) ELISA Kit

DLR-17-OHP-Ge-48T 48T
EUR 562.8
Description: A competitive inhibition quantitative ELISA assay kit for detection of 17-Hydroxyprogesterone (17-OHP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

17-Hydroxyprogesterone (17-OHP) ELISA Kit

DLR-17-OHP-Ge-96T 96T
EUR 729.6
Description: A competitive inhibition quantitative ELISA assay kit for detection of 17-Hydroxyprogesterone (17-OHP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

IL-17 Recombinant Protein

91-015 0.05 mg
EUR 437.1
Description: Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.

IL-17 Recombinant Protein

91-616 0.05 mg
EUR 588.3
Description: Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.

Polyclonal IL-17 Antibody

APR06508G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IL-17 . This antibody is tested and proven to work in the following applications:

Polyclonal IL-17 Antibody

APR06512G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IL-17 . This antibody is tested and proven to work in the following applications:

rHu IL-17-A

AK8249-0005 5µg Ask for price

rHu IL-17-A

AK8249-0025 25µg Ask for price

rHu IL-17-A

AK8249-0100 100µg Ask for price

rHu IL-17-A

AK8249-1000 1mg Ask for price

rHu IL-17-E

AK8299-0005 5µg Ask for price

rHu IL-17-E

AK8299-0025 25µg Ask for price

rHu IL-17-E

AK8299-0100 100µg Ask for price

rHu IL-17-E

AK8299-1000 1mg Ask for price

rHu IL-17-F

AK8312-0005 5µg Ask for price

rHu IL-17-F

AK8312-0025 25µg Ask for price

rHu IL-17-F

AK8312-0100 100µg Ask for price

rHu IL-17-F

AK8312-1000 1mg Ask for price

Mouse Interleukin 17 (IL-17) CLIA Kit

abx195861-96tests 96 tests
EUR 990

Rat Interleukin 17 (IL-17) CLIA Kit

abx195862-96tests 96 tests
EUR 990

Rabbit Interleukin 17,IL-17 ELISA Kit

CN-00640R1 96T
EUR 542.4

Rabbit Interleukin 17,IL-17 ELISA Kit

CN-00640R2 48T
EUR 362.4

Chicken Interleukin 17,IL-17 ELISA Kit

CN-00838C1 96T
EUR 542.4

Chicken Interleukin 17,IL-17 ELISA Kit

CN-00838C2 48T
EUR 362.4

PoFAine interleukin 17,IL-17 ELISA Kit

CN-01210P2 48T
EUR 391.2

PoFAine interleukin 17,IL-17 ELISA Kit

CN-01211P1 96T
EUR 538.8

PoFAine interleukin 17,IL-17 ELISA Kit

CN-01211P2 48T
EUR 358.8

Rat Interleukin 17,IL-17 ELISA KIT

CN-01495R1 96T
EUR 538.8

Rat Interleukin 17,IL-17 ELISA KIT

CN-01495R2 48T
EUR 358.8

Canine Interleukin 17(IL-17)ELISA Kit

CSB-E17935c-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Canine Interleukin 17 (IL-17) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Canine Interleukin 17(IL-17)ELISA Kit

1-CSB-E17935c
  • EUR 1080.00
  • EUR 6571.20
  • EUR 3480.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Canine Interleukin 17(IL-17) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Rat Interleukin 17, IL-17 ELISA KIT

CSB-E07451r-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Rat Interleukin 17, IL-17 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Rat Interleukin 17, IL-17 ELISA KIT

1-CSB-E07451r
  • EUR 723.60
  • EUR 5096.40
  • EUR 2712.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Rat Interleukin 17, IL-17 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Pig interleukin 17, IL-17 ELISA Kit

CSB-E08057p-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Pig interleukin 17, IL-17 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Pig interleukin 17, IL-17 ELISA Kit

1-CSB-E08057p
  • EUR 723.60
  • EUR 5096.40
  • EUR 2712.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Pig interleukin 17, IL-17 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Rabbit Interleukin 17, IL-17 ELISA Kit

CSB-E08058Rb-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Rabbit Interleukin 17, IL-17 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Rabbit Interleukin 17, IL-17 ELISA Kit

1-CSB-E08058Rb
  • EUR 723.60
  • EUR 5096.40
  • EUR 2712.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Rabbit Interleukin 17, IL-17 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Chicken Interleukin 17, IL-17 ELISA Kit

CSB-E04607Ch-24T 1 plate of 24 wells
EUR 198
Description: Quantitativecompetitive ELISA kit for measuring Chicken Interleukin 17, IL-17 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Chicken Interleukin 17, IL-17 ELISA Kit

1-CSB-E04607Ch
  • EUR 723.60
  • EUR 5096.40
  • EUR 2712.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativecompetitive ELISA kit for measuring Chicken Interleukin 17, IL-17 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Interleukin 17, IL-17 ELISA Kit

CSB-E04608m-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Mouse Interleukin 17, IL-17 in samples from serum, plasma, tissue homogenates, cell culture supernates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse Interleukin 17, IL-17 ELISA Kit

1-CSB-E04608m
  • EUR 723.60
  • EUR 5096.40
  • EUR 2712.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Mouse Interleukin 17, IL-17 in samples from serum, plasma, tissue homogenates, cell culture supernates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Bovine Interleukin 17(IL-17) ELISA Kit

CSB-E14207B-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Bovine Interleukin 17 (IL-17) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Bovine Interleukin 17(IL-17) ELISA Kit

1-CSB-E14207B
  • EUR 1080.00
  • EUR 6571.20
  • EUR 3480.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Bovine Interleukin 17(IL-17) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Interleukin 17,IL-17 ELISA Kit

CN-02453M1 96T
EUR 536.4

Mouse Interleukin 17,IL-17 ELISA Kit

CN-02453M2 48T
EUR 355.2

Rat IL-17(Interleukin-17) ELISA Kit

ER0035 96T
EUR 571.5
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 9.375pg/ml

Rabbit IL-17(Interleukin 17) ELISA Kit

ERB0160 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rabbit;Sensitivity: 9.375pg/ml

Porcine IL-17(Interleukin 17) ELISA Kit

EP0090 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Pig;Sensitivity: 9.375pg/ml

Hamster IL-17(Interleukin 17) ELISA Kit

EHA0007 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Hamster;Sensitivity: 18.75pg/ml

Canine IL-17(Interleukin 17) ELISA Kit

ECA0032 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Canine;Sensitivity: 18.75pg/ml

Mouse Interleukin 17(IL-17)ELISA Kit

GA-E0063MS-48T 48T
EUR 403.2

Mouse Interleukin 17(IL-17)ELISA Kit

GA-E0063MS-96T 96T
EUR 640.8

Rabbit Interleukin 17,IL-17 ELISA Kit

GA-E0112RB-48T 48T
EUR 391.2

Rabbit Interleukin 17,IL-17 ELISA Kit

GA-E0112RB-96T 96T
EUR 628.8

Rat Interleukin 17(IL-17)ELISA Kit

GA-E0124RT-48T 48T
EUR 424.8

Rat Interleukin 17(IL-17)ELISA Kit

GA-E0124RT-96T 96T
EUR 685.2

Chicken Interleukin-17, IL-17 ELISA Kit

ELA-E0063d 96 Tests
EUR 1113.6

Porcine Interleukin-17, IL-17 ELISA Kit

ELA-E0063p 96 Tests
EUR 1113.6

Rat Interleukin 17, IL- 17 ELISA Kit

ELA-E0063r 96 Tests
EUR 1063.2

Rabbit Interleukin-17, IL-17 ELISA Kit

ELA-E0063Rb 96 Tests
EUR 1113.6

IL-17 Interleukin-17 Rat Recombinant Protein

PROTQ61453 Regular: 25ug
EUR 380.4
Description: Interleukin-17A Rat Recombinant produced in E.Coli is a homodimeric, non-glycosylated polypeptide chain having a molecular mass of 30 kDa. ;The IL-17A Rat is purified by proprietary chromatographic techniques.

IL-17 Interleukin-17 Mouse Recombinant Protein

PROTQ62386 Regular: 25ug
EUR 380.4
Description: Interleukin-17 Murine Recombinant produced in E.Coli is a homodimeric, non-glycosylated polypeptide chain containing a total of 268 (2x134 a.a.) amino acids and having a molecular mass of 30 kDa. ; The IL-17 is purified by proprietary chromatographic techniques.

Chicken Interleukin 17,IL-17 ELISA Kit

QY-E80084 96T
EUR 511.2

Rat Interleukin 17(IL-17)ELISA Kit

QY-E11529 96T
EUR 433.2

Mouse Interleukin 17(IL-17)ELISA Kit

QY-E20837 96T
EUR 433.2

Rabbit Interleukin 17,IL-17 ELISA Kit

QY-E30186 96T
EUR 448.8

Porcine interleukin-17 (IL-17) ELISA Kit

QY-E40091 96T
EUR 480

Canine Interleukin 17,IL-17 ELISA Kit

QY-E70002 96T
EUR 511.2

General 17-Hydroxyprogesterone (17-OHP) ELISA Kit

RD-17-OHP-Ge-48Tests 48 Tests
EUR 560.4

General 17-Hydroxyprogesterone (17-OHP) ELISA Kit

RD-17-OHP-Ge-96Tests 96 Tests
EUR 775.2

General 17-Hydroxyprogesterone (17-OHP) ELISA Kit

RDR-17-OHP-Ge-48Tests 48 Tests
EUR 585.6

General 17-Hydroxyprogesterone (17-OHP) ELISA Kit

RDR-17-OHP-Ge-96Tests 96 Tests
EUR 811.2

IL-17 Interleukin-17 Human Recombinant Protein, His Tag

PROTQ16552-2 Regular: 10ug
EUR 380.4
Description: Interleukin-17A Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 132 amino acids fragment (24-155) having a molecular weight of 19.62kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. ;The IL-17A His is purified by proprietary chromatographic techniques.

Human IL-17 PicoKine ELISA Kit

EK0430 96 wells
EUR 510
Description: For quantitative detection of human IL-17 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

CymaxTM Human IL-17 ELISA Kit

LF-EK0295 1×96T
EUR 477.6

Human IL-17 ELISA kit (4X96T)

LF-EK50202 4×96T
EUR 2641.2

ELISA kit for Human IL-17

KET6022-48T 48T
EUR 242.4
Description: Quantitative sandwich ELISA for measuring Human IL-17 in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human IL-17

KET6022-5platesof96wells 5 plates of 96 wells
EUR 1292.4
Description: Quantitative sandwich ELISA for measuring Human IL-17 in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human IL-17

KET6022-96T 96T
EUR 346.8
Description: Quantitative sandwich ELISA for measuring Human IL-17 in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Recombinant Murine IL-17 (IL-17A) Protein

PROTQ62386-1 25ug
EUR 380.4
Description: The originally described IL-17 protein, now known as IL-17A, is a disulfide linked homodimer, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant murine IL-17A is a 30.0 kDa disulfide-linked homodimer of two 133 amino acid polypeptide chains.

Human Interleukin 17A (IL-17A/IL-17) ELISA Kit

CSB-E12819h-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 17A (IL-17A/IL-17) in samples from serum, urine, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Interleukin 17A (IL-17A/IL-17) ELISA Kit

1-CSB-E12819h
  • EUR 964.80
  • EUR 6118.80
  • EUR 3244.80
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 17A (IL-17A/IL-17) in samples from serum, urine, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Genorise® Anti-canine IL-17 Polyclonal Antibody

GR105162 100 ug
EUR 525.6

Mouse Interleukin-17 (IL-17) Detection Assay Kit

6708 1 kit
EUR 580.26
Description: Mouse Interleukin-17 (IL-17) Detection Assay Kit

Guinea pig Interleukin 17, IL-17 ELISA Kit

CSB-E13097Gp-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Guinea pig Interleukin 17, IL-17 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Guinea pig Interleukin 17, IL-17 ELISA Kit

1-CSB-E13097Gp
  • EUR 964.80
  • EUR 6118.80
  • EUR 3244.80
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Guinea pig Interleukin 17, IL-17 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

CLIA kit for Mouse IL-17 (Interleukin 17)

E-CL-M0045 1 plate of 96 wells
EUR 700.8
Description: A sandwich CLIA kit for quantitative measurement of Mouse IL-17 (Interleukin 17) in samples from Serum, Plasma, Cell supernatant

CLIA kit for Rat IL-17 (Interleukin 17)

E-CL-R0400 1 plate of 96 wells
EUR 700.8
Description: A sandwich CLIA kit for quantitative measurement of Rat IL-17 (Interleukin 17) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Rabbit IL-17 (Interleukin 17)

E-EL-RB1795 1 plate of 96 wells
EUR 700.8
Description: A sandwich ELISA kit for quantitative measurement of Rabbit IL-17 (Interleukin 17) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Rat Interleukin 17 (IL-17)

KTE100835-48T 48T
EUR 398.4
Description: Quantitative sandwich ELISA for measuring Rat Interleukin 17 (IL-17) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Rat Interleukin 17 (IL-17)

KTE100835-5platesof96wells 5 plates of 96 wells
EUR 2702.4
Description: Quantitative sandwich ELISA for measuring Rat Interleukin 17 (IL-17) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Rat Interleukin 17 (IL-17)

KTE100835-96T 96T
EUR 686.4
Description: Quantitative sandwich ELISA for measuring Rat Interleukin 17 (IL-17) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse IL-17 (Interleukin 17)

E-EL-M0047 1 plate of 96 wells
EUR 452.4
Description: A sandwich ELISA kit for quantitative measurement of Mouse IL-17 (Interleukin 17) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Rat IL-17 (Interleukin 17)

E-EL-R0566 1 plate of 96 wells
EUR 452.4
Description: A sandwich ELISA kit for quantitative measurement of Rat IL-17 (Interleukin 17) in samples from Serum, Plasma, Cell supernatant

IL-17 Receptor alpha Peptide

42-132P 0.1 mg
EUR 405.6
Description: (IN) IL17ra (mouse) Peptide

IL-17 receptor D antibody

22228-100ul 100ul
EUR 468

IL 17 A / F Protein

20-abx263112
  • EUR 1496.40
  • EUR 393.60
  • EUR 276.00
  • 100 ug
  • 10 ug
  • 2 µg

IL 17 A / F Protein

20-abx263114
  • EUR 1496.40
  • EUR 393.60
  • EUR 276.00
  • 100 ug
  • 10 ug
  • 2 µg

Mouse IL-17 ELISA kit

LF-EK50205 1×96T
EUR 777.6

Human Interleukin-17,IL-17A ELISA Kit

ELA-E1700h 96 Tests
EUR 988.8

Genorise® Biotinylated Anti-equine IL-17 Polyclonal Antibody

GR109027 50 mg
EUR 477.6

Genorise® Biotinylated Anti-canine IL-17 Polyclonal Antibody

GR109179 50 mg
EUR 477.6

IL-17 ELISA Kit| Porcine Interleukin 17 ELISA Kit

EF016631 96 Tests
EUR 826.8

IL-17 ELISA Kit| Rat Interleukin-17 ELISA Kit

EF017034 96 Tests
EUR 826.8

IL-17 ELISA Kit| Hamster Interleukin 17 ELISA Kit

EF012647 96 Tests
EUR 826.8

IL-17 ELISA Kit| Mouse Interleukin 17 ELISA Kit

EF012945 96 Tests
EUR 826.8

Recombinant Human IL-17 Receptor A/IL-17RA/CD217 (C-Fc)

CI53-10ug 10ug
EUR 120
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human IL-17 Receptor A/IL-17RA/CD217 (C-Fc)

CI53-1mg 1mg
EUR 1094.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human IL-17 Receptor A/IL-17RA/CD217 (C-Fc)

CI53-500ug 500ug
EUR 850.8
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human IL-17 Receptor A/IL-17RA/CD217 (C-Fc)

CI53-50ug 50ug
EUR 242.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 336

Polyclonal Goat anti-GST μ-form

GST-ANTI-2 50 uL
EUR 336

Polyclonal Goat anti-GST p-form

GST-ANTI-3 50 uL
EUR 336

Mouse IL-17 PicoKine ELISA Kit

EK0431 96 wells
EUR 547.2
Description: For quantitative detection of mouse IL-17 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

IL-17 ELISA Kit (Chicken) (OKEI00119)

OKEI00119 96 Wells
EUR 889.2
Description: Description of target: ;Species reactivity: Chicken;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 9.375 pg/mL

ELISA kit for Mouse IL-17

EK5178 96 tests
EUR 622.8
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse IL-17 in samples from serum, plasma, tissue homogenates and other biological fluids.

CymaxTM Mouse IL-17 ELISA Kit

LF-EK0303 1×96T
EUR 477.6

Mouse IL-17 ELISA kit (4X96T)

LF-EK50206 4×96T
EUR 2641.2

ELISA kit for Mouse IL-17

KET7012-48T 48T
EUR 242.4
Description: Quantitative sandwich ELISA for measuring Mouse IL-17 in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Wild-type mice treated with a control antibody also showed that cells CD19⁺, CD21⁺, sIgG⁺ in the CNS during the peak of EAE severity of the disease and detected serum autoantibodies. In contrast, wild-type mice treated with anti-VLA4 exhibited reduce the level of serum autoantibodies compared to control wild type and KO mice EVA

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