Involvement of ROS-alpha v beta 3 integrin-FAK/Pyk2 in the inhibitory effect of melatonin on U251 glioma cell migration and invasion under hypoxia.

Involvement of ROS-alpha v beta 3 integrin-FAK/Pyk2 in the inhibitory effect of melatonin on U251 glioma cell migration and invasion under hypoxia.

BACKGROUND
Melatonin, which is well-known antioxidant, has been shown to have anti-invasive properties for glioma. However, little is known about the effects of melatonin on the migration and invasion of glioma cells under hypoxia, which is essential for the progress of the microenvironment of the tumor. In addition, the focus of adhesion kinase (FAK) and a proline-rich tyrosine kinase 2 (Pyk2) are closely associated with cell migration and invasion. Therefore, we investigated the possible role of this kinase and related signal in the regulation of the behavior of a human U251 glioma cells with melatonin under hypoxia.


METHOD
The ability of U251 cells migration and invasion of glioma determined by the wound healing and transwell in vitro assays. Production of intracellular reactive oxygen species (ROS) were measured using a fluorescent probe 6-carboxy-2 ‘, 7’-dichorodihydrofluorescein diacetate (DCFH-DA). experiment immunofluorescence and Western blotting analysis is used to detect the protein expression levels. Disturb small RNA (siRNA) was used to silence the expression of specific genes.


RESULTS
Pharmacological concentration (1 mM) of melatonin significantly inhibited the migration and invasion of human glioma U251 cells under hypoxia. The inhibitory effect of melatonin is accompanied by decreased phosphorylation of FAK and Pyk2, and decreased expression of alpha v beta 3 (αvβ3) integrin. Additionally, αvβ3 integrin inhibition by siRNA reduces phosphorylation of FAK / Pyk2 and shows anti-tumor effects are the same as melatonin, indicating the involvement of αvβ3 integrin- FAK / Pyk2 pathway in anti-migration and anti-invasive melatonin. It was also found that melatonin treatment decreased ROS levels in U251 glioma cells cultured under hypoxia. ROS inhibitor apocynin not only inhibit integrin αvβ3 expression and phosphorylation of FAK and Pyk2 level, but also suppresses the migration and invasive capacity U251 glioma cells under hypoxia.


CONCLUSION
These results suggest that melatonin exerts anti-migratory effect and anti-invasive glioma cells in response to hypoxia via ROS-αvβ3 integrin-FAK / Pyk2 signal path. This provides evidence that melatonin may be a potential therapeutic molecules targeting the hypoxic micro glioma.

Involvement of ROS-alpha v beta 3 integrin-FAK/Pyk2 in the inhibitory effect of melatonin on U251 glioma cell migration and invasion under hypoxia.
Involvement of ROS-alpha v beta 3 integrin-FAK/Pyk2 in the inhibitory effect of melatonin on U251 glioma cell migration and invasion under hypoxia.

Epithelial V-like antigen mediate the efficacy of anti-integrin alpha₄ treatment in a mouse model of multiple sclerosis.

Natalizumab inhibit the transmigration of activated T lymphocytes into the brain and is efficacious in multiple sclerosis (MS). However, from the perspective of pharmacogenomics, efficacy and safety in certain patients remains unclear. Here our aim is to analyze the effects of epithelial V-like antigen (EVA) on the anti-alpha₄ integrin (VLA4) efficacy in a mouse model of MS, experimental autoimmune encephalomyelitis (EAE). EVA has previously been characterized in human CD4 + T lymphocytes, mouse thymus development, and epithelial cells of the choroid plexus.

Further analysis here showed expression in B lymphocytes, and increase lymphocyte EVA⁺ after immunization. The following active induction of EAE model MOG³⁵⁻⁵⁵ active immunization, EVA deficient mice developed EAE injury and white matter tissue is more severe than the wild type control. This severe EAE phenotype did not respond to anti-VLA4 treatment. In both the control condition and the anti-VLA4 antibodies, these mice show persistent CNS invasion mature B lymphocytes (CD19⁺, CD21⁺, sIgG⁺), increased serum levels of autoantibodies, and appendages broad and IgG deposition in the lesion containing CD5⁺IgG⁺ cells.

IL-6, Interleukin-6, human

RC212-17 5ug
EUR 104.38

IL-17, Human

HY-P7036 10ug
EUR 211

IL-17

E5-00007 1mg
EUR 960

IL-17

MO15110 500 ug
EUR 910

IL-17

PR27113 5 ug
EUR 191

IL-17

EF014060 96 Tests
EUR 689

Anti-IL-17 alpha antibody

STJ93683 200 µl
EUR 197
Description: Rabbit polyclonal to IL-17Ralpha.

IL-17/IL-17A

E21-021 10ug
EUR 343

IL-6, Interleukin-6, rat

RC252-17 2ug
EUR 104.38

Recombinant Human IL-17

SJB09-03 25µg/vial
EUR 256

Interleukin 17 (IL-17) Antibody

abx234224-100ug 100 ug
EUR 509

Interleukin 17 (IL-17) Antibody

abx234225-100ug 100 ug
EUR 481

Bovine Interleukin 17(IL-17)

QY-E60069 96T
EUR 426

IL-6, Interleukin-6, murine (mouse)

RC232-17 2ug
EUR 104.38

IL-17 Antibody

24784-100ul 100ul
EUR 390

IL-17 Antibody

24789-100ul 100ul
EUR 390

IL-17 Antibody

4877-002mg 0.02 mg
EUR 171.82
Description: IL-17 Antibody: Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines produced by activated T cells and is thought to have a major role in the initiation and perpetuation of rheumatoid arthritis. IL-17 regulates the activities of NF-κB and mitogen-activated protein kinases such as ERK and JNK. In addition, IL-17 stimulates the expression of IL-6 and cyclooxygenase-2 and enhances the production of nitric oxide. IL-17-producing T helper cells (TH-17 cells) have been the subject of much attention due to the importance of IL-17 in the pathogenesis of autoimmune inflammation. Because of its role in autoimmune diseases, it is thought that targeting the production and action of IL-17 would be beneficial therapeutically in these diseases.

IL-17 Antibody

4877-01mg 0.1 mg
EUR 436.42
Description: IL-17 Antibody: Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines produced by activated T cells and is thought to have a major role in the initiation and perpetuation of rheumatoid arthritis. IL-17 regulates the activities of NF-κB and mitogen-activated protein kinases such as ERK and JNK. In addition, IL-17 stimulates the expression of IL-6 and cyclooxygenase-2 and enhances the production of nitric oxide. IL-17-producing T helper cells (TH-17 cells) have been the subject of much attention due to the importance of IL-17 in the pathogenesis of autoimmune inflammation. Because of its role in autoimmune diseases, it is thought that targeting the production and action of IL-17 would be beneficial therapeutically in these diseases.

IL-17 Antibody

4887-002mg 0.02 mg
EUR 171.82
Description: IL-17 Antibody: Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines produced by activated T cells and is thought to have a major role in the initiation and perpetuation of rheumatoid arthritis. IL-17 regulates the activities of NF-κB and mitogen-activated protein kinases such as ERK and JNK. In addition, IL-17 stimulates the expression of IL-6 and cyclooxygenase-2 and enhances the production of nitric oxide. IL-17-producing T helper cells (TH-17 cells) have been the subject of much attention due to the importance of IL-17 in the pathogenesis of autoimmune inflammation. Because of its role in autoimmune diseases, it is thought that targeting the production and action of IL-17 would be beneficial therapeutically in these diseases.

IL-17 Antibody

4887-01mg 0.1 mg
EUR 436.42
Description: IL-17 Antibody: Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines produced by activated T cells and is thought to have a major role in the initiation and perpetuation of rheumatoid arthritis. IL-17 regulates the activities of NF-κB and mitogen-activated protein kinases such as ERK and JNK. In addition, IL-17 stimulates the expression of IL-6 and cyclooxygenase-2 and enhances the production of nitric oxide. IL-17-producing T helper cells (TH-17 cells) have been the subject of much attention due to the importance of IL-17 in the pathogenesis of autoimmune inflammation. Because of its role in autoimmune diseases, it is thought that targeting the production and action of IL-17 would be beneficial therapeutically in these diseases.

IL-17 Peptide

4877P 0.05 mg
EUR 164.75
Description: (NT) IL-17 peptide

IL-17 Peptide

4887P 0.05 mg
EUR 164.75
Description: (IN) IL-17 peptide

IL-17 Antibody

5176-100
EUR 338

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 349

IL-17 Interleukin-17 Human Recombinant Protein

PROTQ16552-1 Regular: 25ug
EUR 317
Description: Interleukin-17A Human Recombinant produced in E.Coli is a homodimeric, non-glycosylated polypeptide chain containing a total of 264 amino acids (2 chains of 132 aa) and having a molecular mass of 31kDa.  ;The IL-17 is purified by proprietary chromatographic techniques.

Human Interleukin 17(IL-17)ELISA Kit

GA-E0081HM-48T 48T
EUR 289

Human Interleukin 17(IL-17)ELISA Kit

GA-E0081HM-96T 96T
EUR 466

Human Interleukin 17,IL-17 ELISA Kit

201-12-0143 96 tests
EUR 440
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Interleukin 17 (IL-17) CLIA Kit

abx195860-96tests 96 tests
EUR 825

Human Interleukin 17(IL-17)ELISA Kit

QY-E04323 96T
EUR 361

Human Interleukin 17,IL-17 ELISA Kit

CN-03335H1 96T
EUR 434

Human Interleukin 17,IL-17 ELISA Kit

CN-03335H2 48T
EUR 284

IL-6, Interleukin-6, monkey (rhesus macaque)

RC222-17 2ug
EUR 104.38

Recombinant Human IL-17 (IL-17A) Protein

PROTQ16552-4 25ug
EUR 317
Description: The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 136 amino acid chains, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules.  Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles.  The six known members of this family, IL-17A through IL-17F, are secreted as homodimers.  IL-17A exhibits cross-species bioactivity between human and murine cells.  Recombinant human IL-17A is a 31.3 kDa disulfide-linked homodimer of two 137 amino acid polypeptide chains.

human IL-17, His tag

E410A10-100 100μg
EUR 960

IL-17 ELISA KIT|Human

EF006939 96 Tests
EUR 689

Human IL-17 ELISA kit

LF-EK50201 1×96T
EUR 648

IL-17 (Human) ELISA Kit

E4628-100
EUR 729

17-Hydroxyprogesterone (17-OHP) ELISA Kit

DLR-17-OHP-Ge-48T 48T
EUR 469
Description: A competitive inhibition quantitative ELISA assay kit for detection of 17-Hydroxyprogesterone (17-OHP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

17-Hydroxyprogesterone (17-OHP) ELISA Kit

DLR-17-OHP-Ge-96T 96T
EUR 608
Description: A competitive inhibition quantitative ELISA assay kit for detection of 17-Hydroxyprogesterone (17-OHP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

IL-17 Interleukin-17 Human Recombinant Protein, HEK

PROTQ16552 Regular: 10ug
EUR 317
Description: IL-17 Human Recombinant produced in HEK cells is a glycosylated homodimer, having a molecular weight range of 30-35kDa due to glycosylation.;The IL-17 is purified by proprietary chromatographic techniques.

ELISA kit for Human IL-17 (Interleukin 17)

E-EL-H0105 1 plate of 96 wells
EUR 377
Description: A sandwich ELISA kit for quantitative measurement of Human IL-17 (Interleukin 17) in samples from Serum, Plasma, Cell supernatant

CLIA kit for Human IL-17 (Interleukin 17)

E-CL-H0104 1 plate of 96 wells
EUR 584
Description: A sandwich CLIA kit for quantitative measurement of Human IL-17 (Interleukin 17) in samples from Serum, Plasma, Cell supernatant

Human Interleukin 17 (IL-17) Detection Assay Kit

6808 1 kit
EUR 483.55
Description: Human Interleukin 17 (IL-17) Detection Assay Kit

General 17-Hydroxyprogesterone (17-OHP) ELISA Kit

RD-17-OHP-Ge-48Tests 48 Tests
EUR 467

General 17-Hydroxyprogesterone (17-OHP) ELISA Kit

RD-17-OHP-Ge-96Tests 96 Tests
EUR 646

General 17-Hydroxyprogesterone (17-OHP) ELISA Kit

RDR-17-OHP-Ge-48Tests 48 Tests
EUR 488

General 17-Hydroxyprogesterone (17-OHP) ELISA Kit

RDR-17-OHP-Ge-96Tests 96 Tests
EUR 676

Polyclonal IL-17 Antibody

APR06508G 0.1 mg
EUR 659
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IL-17 . This antibody is tested and proven to work in the following applications:

Polyclonal IL-17 Antibody

APR06512G 0.1 mg
EUR 659
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IL-17 . This antibody is tested and proven to work in the following applications:

rHu IL-17-A

AK8249-0005 5µg Ask for price

rHu IL-17-A

AK8249-0025 25µg Ask for price

rHu IL-17-A

AK8249-0100 100µg Ask for price

rHu IL-17-A

AK8249-1000 1mg Ask for price

rHu IL-17-E

AK8299-0005 5µg Ask for price

rHu IL-17-E

AK8299-0025 25µg Ask for price

rHu IL-17-E

AK8299-0100 100µg Ask for price

rHu IL-17-E

AK8299-1000 1mg Ask for price

rHu IL-17-F

AK8312-0005 5µg Ask for price

rHu IL-17-F

AK8312-0025 25µg Ask for price

rHu IL-17-F

AK8312-0100 100µg Ask for price

rHu IL-17-F

AK8312-1000 1mg Ask for price

IL-17 Recombinant Protein

91-015 0.05 mg
EUR 364.25
Description: Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.

IL-17 Recombinant Protein

91-616 0.05 mg
EUR 490.25
Description: Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.

Chicken Interleukin 17, IL-17 ELISA Kit

CSB-E04607Ch-24T 1 plate of 24 wells
EUR 165
Description: Quantitativecompetitive ELISA kit for measuring Chicken Interleukin 17, IL-17 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Chicken Interleukin 17, IL-17 ELISA Kit

1-CSB-E04607Ch
  • EUR 603.00
  • EUR 4247.00
  • EUR 2260.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativecompetitive ELISA kit for measuring Chicken Interleukin 17, IL-17 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Interleukin 17, IL-17 ELISA Kit

CSB-E04608m-24T 1 plate of 24 wells
EUR 165
Description: Quantitativesandwich ELISA kit for measuring Mouse Interleukin 17, IL-17 in samples from serum, plasma, tissue homogenates, cell culture supernates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse Interleukin 17, IL-17 ELISA Kit

1-CSB-E04608m
  • EUR 603.00
  • EUR 4247.00
  • EUR 2260.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Mouse Interleukin 17, IL-17 in samples from serum, plasma, tissue homogenates, cell culture supernates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Canine Interleukin 17(IL-17)ELISA Kit

CSB-E17935c-24T 1 plate of 24 wells
EUR 165
Description: Quantitativesandwich ELISA kit for measuring Canine Interleukin 17 (IL-17) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Canine Interleukin 17(IL-17)ELISA Kit

1-CSB-E17935c
  • EUR 900.00
  • EUR 5476.00
  • EUR 2900.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Canine Interleukin 17(IL-17) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Rat Interleukin 17, IL-17 ELISA KIT

CSB-E07451r-24T 1 plate of 24 wells
EUR 165
Description: Quantitativesandwich ELISA kit for measuring Rat Interleukin 17, IL-17 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Rat Interleukin 17, IL-17 ELISA KIT

1-CSB-E07451r
  • EUR 603.00
  • EUR 4247.00
  • EUR 2260.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Rat Interleukin 17, IL-17 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Pig interleukin 17, IL-17 ELISA Kit

CSB-E08057p-24T 1 plate of 24 wells
EUR 165
Description: Quantitativesandwich ELISA kit for measuring Pig interleukin 17, IL-17 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Pig interleukin 17, IL-17 ELISA Kit

1-CSB-E08057p
  • EUR 603.00
  • EUR 4247.00
  • EUR 2260.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Pig interleukin 17, IL-17 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Rabbit Interleukin 17, IL-17 ELISA Kit

CSB-E08058Rb-24T 1 plate of 24 wells
EUR 165
Description: Quantitativesandwich ELISA kit for measuring Rabbit Interleukin 17, IL-17 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Rabbit Interleukin 17, IL-17 ELISA Kit

1-CSB-E08058Rb
  • EUR 603.00
  • EUR 4247.00
  • EUR 2260.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Rabbit Interleukin 17, IL-17 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Bovine Interleukin 17(IL-17) ELISA Kit

CSB-E14207B-24T 1 plate of 24 wells
EUR 165
Description: Quantitativesandwich ELISA kit for measuring Bovine Interleukin 17 (IL-17) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Bovine Interleukin 17(IL-17) ELISA Kit

1-CSB-E14207B
  • EUR 900.00
  • EUR 5476.00
  • EUR 2900.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Bovine Interleukin 17(IL-17) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

IL-17 Interleukin-17 Rat Recombinant Protein

PROTQ61453 Regular: 25ug
EUR 317
Description: Interleukin-17A Rat Recombinant produced in E.Coli is a homodimeric, non-glycosylated polypeptide chain having a molecular mass of 30 kDa. ;The IL-17A Rat is purified by proprietary chromatographic techniques.

IL-17 Interleukin-17 Mouse Recombinant Protein

PROTQ62386 Regular: 25ug
EUR 317
Description: Interleukin-17 Murine Recombinant produced in E.Coli is a homodimeric, non-glycosylated polypeptide chain containing a total of 268 (2x134 a.a.) amino acids and having a molecular mass of 30 kDa. ; The IL-17 is purified by proprietary chromatographic techniques.

Rabbit Interleukin 17,IL-17 ELISA Kit

GA-E0112RB-48T 48T
EUR 326

Rabbit Interleukin 17,IL-17 ELISA Kit

GA-E0112RB-96T 96T
EUR 524

Rat Interleukin 17(IL-17)ELISA Kit

GA-E0124RT-48T 48T
EUR 354

Rat Interleukin 17(IL-17)ELISA Kit

GA-E0124RT-96T 96T
EUR 571

Mouse Interleukin 17(IL-17)ELISA Kit

GA-E0063MS-48T 48T
EUR 336

Mouse Interleukin 17(IL-17)ELISA Kit

GA-E0063MS-96T 96T
EUR 534

Mouse Interleukin 17 (IL-17) CLIA Kit

abx195861-96tests 96 tests
EUR 825

Rat Interleukin 17 (IL-17) CLIA Kit

abx195862-96tests 96 tests
EUR 825

Rabbit IL-17(Interleukin 17) ELISA Kit

ERB0160 96T
EUR 567.6
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rabbit;Sensitivity: 9.375pg/ml

Rabbit Interleukin 17,IL-17 ELISA Kit

QY-E30186 96T
EUR 374

Porcine interleukin-17 (IL-17) ELISA Kit

QY-E40091 96T
EUR 400

Canine Interleukin 17,IL-17 ELISA Kit

QY-E70002 96T
EUR 426

Chicken Interleukin 17,IL-17 ELISA Kit

QY-E80084 96T
EUR 426

Rat Interleukin 17(IL-17)ELISA Kit

QY-E11529 96T
EUR 361

Mouse Interleukin 17(IL-17)ELISA Kit

QY-E20837 96T
EUR 361

Hamster IL-17(Interleukin 17) ELISA Kit

EHA0007 96T
EUR 567.6
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Hamster;Sensitivity: 18.75pg/ml

Canine IL-17(Interleukin 17) ELISA Kit

ECA0032 96T
EUR 567.6
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Canine;Sensitivity: 18.75pg/ml

Chicken IL-17(Interleukin 17) ELISA Kit

ECH0038 96T
EUR 567.6
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Chicken;Sensitivity: 9.375pg/ml

Porcine IL-17(Interleukin 17) ELISA Kit

EP0090 96T
EUR 567.6
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Pig;Sensitivity: 9.375pg/ml

Rat IL-17(Interleukin-17) ELISA Kit

ER0035 96T
EUR 476.25
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 9.375pg/ml

Mouse Interleukin 17,IL-17 ELISA Kit

CN-02453M1 96T
EUR 447

Mouse Interleukin 17,IL-17 ELISA Kit

CN-02453M2 48T
EUR 296

Rabbit Interleukin 17,IL-17 ELISA Kit

CN-00640R1 96T
EUR 452

Rabbit Interleukin 17,IL-17 ELISA Kit

CN-00640R2 48T
EUR 302

Chicken Interleukin 17,IL-17 ELISA Kit

CN-00838C1 96T
EUR 452

Chicken Interleukin 17,IL-17 ELISA Kit

CN-00838C2 48T
EUR 302

PoFAine interleukin 17,IL-17 ELISA Kit

CN-01210P2 48T
EUR 326

PoFAine interleukin 17,IL-17 ELISA Kit

CN-01211P1 96T
EUR 449

PoFAine interleukin 17,IL-17 ELISA Kit

CN-01211P2 48T
EUR 299

Rat Interleukin 17,IL-17 ELISA KIT

CN-01495R1 96T
EUR 449

Rat Interleukin 17,IL-17 ELISA KIT

CN-01495R2 48T
EUR 299

Chicken Interleukin-17, IL-17 ELISA Kit

ELA-E0063d 96 Tests
EUR 928

Porcine Interleukin-17, IL-17 ELISA Kit

ELA-E0063p 96 Tests
EUR 928

Rat Interleukin 17, IL- 17 ELISA Kit

ELA-E0063r 96 Tests
EUR 886

Rabbit Interleukin-17, IL-17 ELISA Kit

ELA-E0063Rb 96 Tests
EUR 928

IL-17 Interleukin-17 Human Recombinant Protein, His Tag

PROTQ16552-2 Regular: 10ug
EUR 317
Description: Interleukin-17A Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 132 amino acids fragment (24-155) having a molecular weight of 19.62kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. ;The IL-17A His is purified by proprietary chromatographic techniques.

Genorise® Anti-canine IL-17 Polyclonal Antibody

GR105162 100 ug
EUR 438

ELISA kit for Human IL-17

KET6022-48T 48T
EUR 202
Description: Quantitative sandwich ELISA for measuring Human IL-17 in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human IL-17

KET6022-5platesof96wells 5 plates of 96 wells
EUR 1077
Description: Quantitative sandwich ELISA for measuring Human IL-17 in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human IL-17

KET6022-96T 96T
EUR 289
Description: Quantitative sandwich ELISA for measuring Human IL-17 in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human IL-17

EK0474 96 tests
EUR 427
Description: Enzyme-linked immunosorbent assay kit for quantification of Human IL-17 in samples from serum, plasma, tissue homogenates and other biological fluids.

CymaxTM Human IL-17 ELISA Kit

LF-EK0295 1×96T
EUR 398

Human IL-17 ELISA kit (4X96T)

LF-EK50202 4×96T
EUR 2201

Recombinant Murine IL-17 (IL-17A) Protein

PROTQ62386-1 25ug
EUR 317
Description: The originally described IL-17 protein, now known as IL-17A, is a disulfide linked homodimer, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant murine IL-17A is a 30.0 kDa disulfide-linked homodimer of two 133 amino acid polypeptide chains.

Human Interleukin 17A (IL-17A/IL-17) ELISA Kit

CSB-E12819h-24T 1 plate of 24 wells
EUR 165
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 17A (IL-17A/IL-17) in samples from serum, urine, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Interleukin 17A (IL-17A/IL-17) ELISA Kit

1-CSB-E12819h
  • EUR 804.00
  • EUR 5099.00
  • EUR 2704.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 17A (IL-17A/IL-17) in samples from serum, urine, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Guinea pig Interleukin 17, IL-17 ELISA Kit

CSB-E13097Gp-24T 1 plate of 24 wells
EUR 165
Description: Quantitativesandwich ELISA kit for measuring Guinea pig Interleukin 17, IL-17 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Guinea pig Interleukin 17, IL-17 ELISA Kit

1-CSB-E13097Gp
  • EUR 804.00
  • EUR 5099.00
  • EUR 2704.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Guinea pig Interleukin 17, IL-17 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

ELISA kit for Mouse IL-17 (Interleukin 17)

E-EL-M0047 1 plate of 96 wells
EUR 377
Description: A sandwich ELISA kit for quantitative measurement of Mouse IL-17 (Interleukin 17) in samples from Serum, Plasma, Cell supernatant

CLIA kit for Mouse IL-17 (Interleukin 17)

E-CL-M0045 1 plate of 96 wells
EUR 584
Description: A sandwich CLIA kit for quantitative measurement of Mouse IL-17 (Interleukin 17) in samples from Serum, Plasma, Cell supernatant

CLIA kit for Rat IL-17 (Interleukin 17)

E-CL-R0400 1 plate of 96 wells
EUR 584
Description: A sandwich CLIA kit for quantitative measurement of Rat IL-17 (Interleukin 17) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Rat Interleukin 17 (IL-17)

KTE100835-48T 48T
EUR 332
Description: Quantitative sandwich ELISA for measuring Rat Interleukin 17 (IL-17) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Rat Interleukin 17 (IL-17)

KTE100835-5platesof96wells 5 plates of 96 wells
EUR 2252
Description: Quantitative sandwich ELISA for measuring Rat Interleukin 17 (IL-17) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Rat Interleukin 17 (IL-17)

KTE100835-96T 96T
EUR 572
Description: Quantitative sandwich ELISA for measuring Rat Interleukin 17 (IL-17) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Rat IL-17 (Interleukin 17)

E-EL-R0566 1 plate of 96 wells
EUR 377
Description: A sandwich ELISA kit for quantitative measurement of Rat IL-17 (Interleukin 17) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Rabbit IL-17 (Interleukin 17)

E-EL-RB1795 1 plate of 96 wells
EUR 584
Description: A sandwich ELISA kit for quantitative measurement of Rabbit IL-17 (Interleukin 17) in samples from Serum, Plasma, Cell supernatant

Mouse Interleukin-17 (IL-17) Detection Assay Kit

6708 1 kit
EUR 483.55
Description: Mouse Interleukin-17 (IL-17) Detection Assay Kit

Guinea pig IL-17(Interleukin 17) ELISA Kit

EGP0028 96T
EUR 567.6
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Guinea pig;Sensitivity: 18.75pg/ml

IL-17 receptor D antibody

22228-100ul 100ul
EUR 390

IL 17 A / F Protein

20-abx263112
  • EUR 1247.00
  • EUR 328.00
  • EUR 230.00
  • 100 ug
  • 10 ug
  • 2 µg

IL 17 A / F Protein

20-abx263114
  • EUR 1247.00
  • EUR 328.00
  • EUR 230.00
  • 100 ug
  • 10 ug
  • 2 µg

Mouse IL-17 ELISA kit

LF-EK50205 1×96T
EUR 648

IL-17 Receptor alpha Peptide

42-132P 0.1 mg
EUR 338
Description: (IN) IL17ra (mouse) Peptide

Genorise® Biotinylated Anti-equine IL-17 Polyclonal Antibody

GR109027 50 mg
EUR 398

Genorise® Biotinylated Anti-canine IL-17 Polyclonal Antibody

GR109179 50 mg
EUR 398

Human Interleukin-17,IL-17A ELISA Kit

ELA-E1700h 96 Tests
EUR 824

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 280

Polyclonal Goat anti-GST μ-form

GST-ANTI-2 50 uL
EUR 280

Polyclonal Goat anti-GST p-form

GST-ANTI-3 50 uL
EUR 280

IL-17 ELISA Kit| Porcine Interleukin 17 ELISA Kit

EF016631 96 Tests
EUR 689

IL-17 ELISA Kit| Rat Interleukin-17 ELISA Kit

EF017034 96 Tests
EUR 689

IL-17 ELISA Kit| Hamster Interleukin 17 ELISA Kit

EF012647 96 Tests
EUR 689

IL-17 ELISA Kit| Mouse Interleukin 17 ELISA Kit

EF012945 96 Tests
EUR 689

FT3 (Free triiodothyronine) ELISA test

17 96T/Box Ask for price
Description: ELISA based test for quantitative detection of FT3 (Free triiodothyronine)

Recombinant Human IL-17 Receptor A/IL-17RA/CD217 (C-Fc)

CI53-10ug 10ug
EUR 100
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human IL-17 Receptor A/IL-17RA/CD217 (C-Fc)

CI53-1mg 1mg
EUR 912
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human IL-17 Receptor A/IL-17RA/CD217 (C-Fc)

CI53-500ug 500ug
EUR 709
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human IL-17 Receptor A/IL-17RA/CD217 (C-Fc)

CI53-50ug 50ug
EUR 202
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

ELISA kit for Mouse IL-17

KET7012-5platesof96wells 5 plates of 96 wells
EUR 1077
Description: Quantitative sandwich ELISA for measuring Mouse IL-17 in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse IL-17

KET7012-96T 96T
EUR 289
Description: Quantitative sandwich ELISA for measuring Mouse IL-17 in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Rat IL-17

KET9005-48T 48T
EUR 202
Description: Quantitative sandwich ELISA for measuring Rat IL-17 in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse IL-17

KET7012-48T 48T
EUR 202
Description: Quantitative sandwich ELISA for measuring Mouse IL-17 in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Rat IL-17

KET9005-5platesof96wells 5 plates of 96 wells
EUR 1077
Description: Quantitative sandwich ELISA for measuring Rat IL-17 in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Rat IL-17

KET9005-96T 96T
EUR 289
Description: Quantitative sandwich ELISA for measuring Rat IL-17 in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Wild-type mice treated with a control antibody also showed that cells CD19⁺, CD21⁺, sIgG⁺ in the CNS during the peak of EAE severity of the disease and detected serum autoantibodies. In contrast, wild-type mice treated with anti-VLA4 exhibited reduce the level of serum autoantibodies compared to control wild type and KO mice EVA

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