Involvement of ROS-alpha v beta 3 integrin-FAK/Pyk2 in the inhibitory effect of melatonin on U251 glioma cell migration and invasion under hypoxia.

Involvement of ROS-alpha v beta 3 integrin-FAK/Pyk2 in the inhibitory effect of melatonin on U251 glioma cell migration and invasion under hypoxia.

BACKGROUND
Melatonin, which is well-known antioxidant, has been shown to have anti-invasive properties for glioma. However, little is known about the effects of melatonin on the migration and invasion of glioma cells under hypoxia, which is essential for the progress of the microenvironment of the tumor. In addition, the focus of adhesion kinase (FAK) and a proline-rich tyrosine kinase 2 (Pyk2) are closely associated with cell migration and invasion. Therefore, we investigated the possible role of this kinase and related signal in the regulation of the behavior of a human U251 glioma cells with melatonin under hypoxia.


METHOD
The ability of U251 cells migration and invasion of glioma determined by the wound healing and transwell in vitro assays. Production of intracellular reactive oxygen species (ROS) were measured using a fluorescent probe 6-carboxy-2 ‘, 7’-dichorodihydrofluorescein diacetate (DCFH-DA). experiment immunofluorescence and Western blotting analysis is used to detect the protein expression levels. Disturb small RNA (siRNA) was used to silence the expression of specific genes.


RESULTS
Pharmacological concentration (1 mM) of melatonin significantly inhibited the migration and invasion of human glioma U251 cells under hypoxia. The inhibitory effect of melatonin is accompanied by decreased phosphorylation of FAK and Pyk2, and decreased expression of alpha v beta 3 (αvβ3) integrin. Additionally, αvβ3 integrin inhibition by siRNA reduces phosphorylation of FAK / Pyk2 and shows anti-tumor effects are the same as melatonin, indicating the involvement of αvβ3 integrin- FAK / Pyk2 pathway in anti-migration and anti-invasive melatonin. It was also found that melatonin treatment decreased ROS levels in U251 glioma cells cultured under hypoxia. ROS inhibitor apocynin not only inhibit integrin αvβ3 expression and phosphorylation of FAK and Pyk2 level, but also suppresses the migration and invasive capacity U251 glioma cells under hypoxia.


CONCLUSION
These results suggest that melatonin exerts anti-migratory effect and anti-invasive glioma cells in response to hypoxia via ROS-αvβ3 integrin-FAK / Pyk2 signal path. This provides evidence that melatonin may be a potential therapeutic molecules targeting the hypoxic micro glioma.

Involvement of ROS-alpha v beta 3 integrin-FAK/Pyk2 in the inhibitory effect of melatonin on U251 glioma cell migration and invasion under hypoxia.
Involvement of ROS-alpha v beta 3 integrin-FAK/Pyk2 in the inhibitory effect of melatonin on U251 glioma cell migration and invasion under hypoxia.

Epithelial V-like antigen mediate the efficacy of anti-integrin alpha₄ treatment in a mouse model of multiple sclerosis.

Natalizumab inhibit the transmigration of activated T lymphocytes into the brain and is efficacious in multiple sclerosis (MS). However, from the perspective of pharmacogenomics, efficacy and safety in certain patients remains unclear. Here our aim is to analyze the effects of epithelial V-like antigen (EVA) on the anti-alpha₄ integrin (VLA4) efficacy in a mouse model of MS, experimental autoimmune encephalomyelitis (EAE). EVA has previously been characterized in human CD4 + T lymphocytes, mouse thymus development, and epithelial cells of the choroid plexus.

Further analysis here showed expression in B lymphocytes, and increase lymphocyte EVA⁺ after immunization. The following active induction of EAE model MOG³⁵⁻⁵⁵ active immunization, EVA deficient mice developed EAE injury and white matter tissue is more severe than the wild type control. This severe EAE phenotype did not respond to anti-VLA4 treatment. In both the control condition and the anti-VLA4 antibodies, these mice show persistent CNS invasion mature B lymphocytes (CD19⁺, CD21⁺, sIgG⁺), increased serum levels of autoantibodies, and appendages broad and IgG deposition in the lesion containing CD5⁺IgG⁺ cells.

anti- IL-17 antibody

FNab04224 100µg
EUR 658.5
Description: Antibody raised against IL-17

anti- IL-17 antibody

FNab04225 100µg
EUR 606.3
Description: Antibody raised against IL-17

Anti-IL-17 Antibody

ER1706-91 100ul
EUR 189
Description: Cytokines are small, soluble proteins with pleiotropic effects on a variety of cell types. Cytokines have a regulatory function over the immune system and mediate aspects of inflammatory response. They exert their biological effects through the binding of membrane-bound receptors which, in turn, initiate signal transduction cascades and elicit physiological changes in their target cell. Interleukin-17 (IL-17) and its cognate receptor, IL-17R, are an example of such a cytokine receptor pair. Originally identified as a rodent cDNA termed CTLA8, IL-17 is capable of inducing the secretion of IL-6 and IL-8 and augmenting the expression of ICAM-1 in human fibroblast cultures. The IL-17 protein exhibits a striking degree of homology with the HSV13 protein which mimics its function. The IL-17 receptor is a type I transmembrane protein 864 amino acids in length, that is highly expressed in spleen and kidney.

Anti-IL-17 antibody

PAab04224 100 ug
EUR 463.2

Anti-Human IL-17 receptor Antibody

101-M484 100 µg
EUR 399
Description: IL-17 binds to IL-17 receptors (IL-17 R), which share no homology with any known family of receptors. While the expression of IL-17 is restricted to activated T cells, IL-17 R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested. The amino acid sequence of human IL-17 R is 69% identical to mouse IL-17 R.

Human IL-17 protein

PRP100289-100ug 100 μg
EUR 1029
Description: Human IL-17 protein, expressed in E. coli

Human IL-17 protein

PRP100289-1mg 1 mg
EUR 7139
Description: Human IL-17 protein, expressed in E. coli

Human IL-17 protein

PRP100289-5ug 5 μg
EUR 149
Description: Human IL-17 protein, expressed in E. coli

Human IL-17 protein

PRP100290-100ug 100 μg
EUR 1029
Description: Human IL-17 protein, expressed in CHO Stable Cells

Human IL-17 protein

PRP100290-1mg 1 mg
EUR 6249
Description: Human IL-17 protein, expressed in CHO Stable Cells

Human IL-17 protein

PRP100290-5ug 5 μg
EUR 129
Description: Human IL-17 protein, expressed in CHO Stable Cells

Recombinant Human IL-17

HEILP-1702 5ug Ask for price

Recombinant Human IL-17

SJB09-03 25µg/vial
EUR 307.2

Anti-Mouse IL-17 Antibody

103-M411 100 µg
EUR 399
Description: The IL-17 family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL-17E is mainly produced by Th2 cells and recruits eosinophils to lung tissue. IL-17C has a very restricted expression pattern but has been detected in adult prostate and fetal kidney libraries.

Anti-IL-17 alpha antibody

STJ93683 200 µl
EUR 236.4
Description: Rabbit polyclonal to IL-17Ralpha.

Anti-Human IL-17 (IL-17A) Goat Polyclonal Antibody

TA328238 100 µg Ask for price

Rabbit anti-IL-17 Antibody

DL90598A-100ul 100 ul
EUR 299
Description: CTLA8; IL17; Interleukin-17A; IL-17; IL-17A; Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8

Rabbit anti-IL-17 Antibody

DL90598A-50ul 50 ul
EUR 209.3
Description: CTLA8; IL17; Interleukin-17A; IL-17; IL-17A; Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8

Rabbit anti-IL-17 Antibody

YLD4293-100ul 100 ul
EUR 320
Description: Rabbit polyclonal antibody to IL-17

Rabbit anti-IL-17 Antibody

YLD4293-50ul 50 ul
EUR 200
Description: Rabbit polyclonal antibody to IL-17

Anti-Human IL-17 (IL-17A) Rabbit Polyclonal Antibody

TA328239 100 µg Ask for price

Human Interleukin 17 (IL-17) CLIA Kit

abx195860-96tests 96 tests
EUR 990

Human IL-17 -Interleukin 17- CLIA Kit

E-CL-H0104-24Tests 24 Tests
EUR 180
Description: Sandwich

Human IL-17 -Interleukin 17- CLIA Kit

E-CL-H0104-48Tests 48 Tests
EUR 546
Description: Sandwich

Human IL-17 -Interleukin 17- CLIA Kit

E-CL-H0104-96Tests 96 Tests
EUR 682
Description: Sandwich

Human IL-17 -Interleukin 17- CLIA Kit

E-CL-H0104-96Tests10 96 Tests *10
EUR 6820
Description: Sandwich

Human IL-17 -Interleukin 17- CLIA Kit

E-CL-H0104-96Tests5 96 Tests *5
EUR 3410
Description: Sandwich

Human Interleukin 17,IL-17 ELISA Kit

201-12-0143 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Interleukin 17(IL-17) Elisa Kit

EK711084 96 Wells
EUR 0.14

Human IL-17 (Interleukin 17) ELISA Kit

EKE60099-5x96T 5x96T
EUR 2667.6

Human IL-17 (Interleukin 17) ELISA Kit

EKE60099-96T 96T
EUR 561.6

Human Interleukin 17(IL-17)ELISA Kit

GA-E0081HM-48T 48T
EUR 346.8

Human Interleukin 17(IL-17)ELISA Kit

GA-E0081HM-96T 96T
EUR 559.2

Human IL-17(Interleukin 17) ELISA Kit

E39EH3267 96T
EUR 595

Human Interleukin 17,IL-17 ELISA Kit

CN-03335H1 96T
EUR 520.8

Human Interleukin 17,IL-17 ELISA Kit

CN-03335H2 48T
EUR 340.8

Human Interleukin 17(IL-17)ELISA Kit

QY-E04323 96T
EUR 433.2

Human Interleukin 17(IL-17) ELISA Kit

NSL1920Hu 96 wells
EUR 468

Human Interleukin 17,IL-17 ELISA Kit

SL0978Hu 96 Tests
EUR 468

Human Interleukin 17,IL-17 ELISA Kit

YLA1538HU-48T 48T Ask for price

Human Interleukin 17,IL-17 ELISA Kit

YLA1538HU-96T 96T Ask for price

Human Interleukin-17 (IL-17) ELISA Kit

IHUIL17KT each
EUR 702
Description: Human Interleukin-17 (IL-17) ELISA Kit

Human IL-17 /IL-17A ELISA kit

E22-HC170.48 48T
EUR 295

Human IL-17 /IL-17A ELISA kit

E22-HC170.96 96T
EUR 395

Recombinant Human Interleukin-17(rHu IL-17)

70117 25ul
EUR 235
Description: Fully biologically active when compared to standard. The ED50 as determined by inducing IL-6 secretion of murine NIH/3T3 cells is less than 7.5 ng/ml, corresponding to a specific activity of > 1.3 × 105 IU/mg.

IL-17 Interleukin-17 Human Recombinant Protein

PROTQ16552-1 Regular: 25ug
EUR 380.4
Description: Interleukin-17A Human Recombinant produced in E.Coli is a homodimeric, non-glycosylated polypeptide chain containing a total of 264 amino acids (2 chains of 132 aa) and having a molecular mass of 31kDa.  ;The IL-17 is purified by proprietary chromatographic techniques.

Recombinant Human IL-17 (IL-17A) Protein

PROTQ16552-4 25ug
EUR 380.4
Description: The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 136 amino acid chains, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules.  Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles.  The six known members of this family, IL-17A through IL-17F, are secreted as homodimers.  IL-17A exhibits cross-species bioactivity between human and murine cells.  Recombinant human IL-17A is a 31.3 kDa disulfide-linked homodimer of two 137 amino acid polypeptide chains.

Anti-Human IL-17 (CTLA-8) Antibody

101-M783 100 µg
EUR 399
Description: The IL-17 family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL-17E is mainly produced by Th2 cells and recruits eosinophils to lung tissue. IL-17C has a very restricted expression pattern but has been detected in adult prostate and fetal kidney libraries.

human IL-17, His tag

E410A10-100 100μg
EUR 700
Description: Inflammation Storm Cytokine

Human IL-17 ELISA Kit

E16HE0054 96T
EUR 733.33

Human IL-17 ELISA KIT

E16HE0054-048 48 wells
EUR 295

Human IL-17 ELISA KIT

E16HE0054-096 96 wells
EUR 395

IL-17 ELISA KIT|Human

EF006939 96 Tests
EUR 826.8

Human IL-17 ELISA KIT

E42EH-11 96T/48T Ask for price

IL-17 (Human) ELISA Kit

E4628-100 each
EUR 874.8

Human IL-17 ELISA kit

LF-EK50201 1×96T
EUR 777.6

Human IL-17 ELISA Kit

RK00397 96 Tests
EUR 280

Human IL-17 ELISA Kit

GWB-ZZD054 1x96 well plate Ask for price

Human IL-17 GENLISA ELISA

KBH0142 1 x 96 wells
EUR 286

Biotinylated Anti-Human IL-17 (IL-17A) Goat Polyclonal Antibody

TA328237 50 µg Ask for price

Biotinylated Anti-Human IL-17 (IL-17A) Rabbit Polyclonal Antibody

TA328236 50 µg Ask for price

CLIA kit for Human IL-17 (Interleukin 17)

E-CL-H0104 1 plate of 96 wells
EUR 700.8
Description: A sandwich CLIA kit for quantitative measurement of Human IL-17 (Interleukin 17) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human IL-17 (Interleukin 17)

E-EL-H0105 1 plate of 96 wells
EUR 452.4
Description: A sandwich ELISA kit for quantitative measurement of Human IL-17 (Interleukin 17) in samples from Serum, Plasma, Cell supernatant

Human Interleukin 17 (IL-17) Detection Assay Kit

6808 1 kit
EUR 357
Description: Culture Media, Serum, Plasma

IL-17 Interleukin-17 Human Recombinant Protein, HEK

PROTQ16552 Regular: 10ug
EUR 380.4
Description: IL-17 Human Recombinant produced in HEK cells is a glycosylated homodimer, having a molecular weight range of 30-35kDa due to glycosylation.;The IL-17 is purified by proprietary chromatographic techniques.

Rat Anti-Mouse IL-17, Antibody

GWB-58C273 0.5 mg Ask for price

Rat Anti-Mouse IL-17, Antibody

GWB-47F187 0.5 mg Ask for price

Rat Anti-Mouse IL-17, Antibody

GWB-1DEA14 0.5 mg Ask for price

Rat Anti-Mouse IL-17, Antibody

GWB-F6EA7C 0.5 mg Ask for price

Anti-Mouse IL-17 receptor Antibody

103-M245 100 µg
EUR 399
Description: IL-17 binds to IL-17 receptors (IL-17 R), which share no homology with any known family of receptors. While the expression of IL-17 is restricted to activated T cells, IL-17 R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested. The amino acid sequence of human IL-17 R is 69% identical to mouse IL-17 R.

Rat Monoclonal anti-mouse IL-17

mAP-0262 100ug
EUR 250

Interleukin 17 (IL-17) Antibody

abx234224-100ug 100 ug
EUR 610.8

Interleukin 17 (IL-17) Antibody

abx234225-100ug 100 ug
EUR 577.2

IL-17/Interleukin-17, Antibody

GWB-F0E090 1 ml Ask for price

IL-17 Antibody

24784-100ul 100ul
EUR 468

IL-17 Antibody

24789-100ul 100ul
EUR 468

IL-17 Antibody

4877-002mg 0.02 mg
EUR 206.18
Description: IL-17 Antibody: Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines produced by activated T cells and is thought to have a major role in the initiation and perpetuation of rheumatoid arthritis. IL-17 regulates the activities of NF-κB and mitogen-activated protein kinases such as ERK and JNK. In addition, IL-17 stimulates the expression of IL-6 and cyclooxygenase-2 and enhances the production of nitric oxide. IL-17-producing T helper cells (TH-17 cells) have been the subject of much attention due to the importance of IL-17 in the pathogenesis of autoimmune inflammation. Because of its role in autoimmune diseases, it is thought that targeting the production and action of IL-17 would be beneficial therapeutically in these diseases.

IL-17 Antibody

4877-01mg 0.1 mg
EUR 523.7
Description: IL-17 Antibody: Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines produced by activated T cells and is thought to have a major role in the initiation and perpetuation of rheumatoid arthritis. IL-17 regulates the activities of NF-κB and mitogen-activated protein kinases such as ERK and JNK. In addition, IL-17 stimulates the expression of IL-6 and cyclooxygenase-2 and enhances the production of nitric oxide. IL-17-producing T helper cells (TH-17 cells) have been the subject of much attention due to the importance of IL-17 in the pathogenesis of autoimmune inflammation. Because of its role in autoimmune diseases, it is thought that targeting the production and action of IL-17 would be beneficial therapeutically in these diseases.

IL-17 Antibody

4887-002mg 0.02 mg
EUR 206.18
Description: IL-17 Antibody: Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines produced by activated T cells and is thought to have a major role in the initiation and perpetuation of rheumatoid arthritis. IL-17 regulates the activities of NF-κB and mitogen-activated protein kinases such as ERK and JNK. In addition, IL-17 stimulates the expression of IL-6 and cyclooxygenase-2 and enhances the production of nitric oxide. IL-17-producing T helper cells (TH-17 cells) have been the subject of much attention due to the importance of IL-17 in the pathogenesis of autoimmune inflammation. Because of its role in autoimmune diseases, it is thought that targeting the production and action of IL-17 would be beneficial therapeutically in these diseases.

IL-17 Antibody

4887-01mg 0.1 mg
EUR 523.7
Description: IL-17 Antibody: Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines produced by activated T cells and is thought to have a major role in the initiation and perpetuation of rheumatoid arthritis. IL-17 regulates the activities of NF-κB and mitogen-activated protein kinases such as ERK and JNK. In addition, IL-17 stimulates the expression of IL-6 and cyclooxygenase-2 and enhances the production of nitric oxide. IL-17-producing T helper cells (TH-17 cells) have been the subject of much attention due to the importance of IL-17 in the pathogenesis of autoimmune inflammation. Because of its role in autoimmune diseases, it is thought that targeting the production and action of IL-17 would be beneficial therapeutically in these diseases.

IL-17 Antibody

F42568-0.4ML 0.4 ml
EUR 322.15
Description: The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

IL-17 antibody

E39-04224 100ug/100ul
EUR 225
Description: Available in various conjugation types.

IL-17 Antibody

5176-100 each
EUR 405.6

IL-17 antibody

CAF50560-100ug 100ug
EUR 338

IL-17 Antibody

R35097-100UG 100 ug
EUR 339.15
Description: Additional name(s) for this target protein: Interleukin 17A; IL17A

IL-17 Antibody

R36188-100UG 100 ug
EUR 339.15
Description: Additional name(s) for this target protein: Interleukin 17A antibody, IL17A, CTLA8

Anti-CTLA-8 / IL-17a Reference Antibody (UCB anti-IL-17)

E24CHA778 100 μg
EUR 225
Description: Available in various conjugation types.

Mouse Monoclonal anti-human CTLA-8 (IL-17)

hAP-0372 100ug
EUR 250

Mouse Monoclonal anti-human CTLA-8 (IL-17)

hAP-0372A 100ug
EUR 250

Sheep Polyclonal anti-Human CTLA-8 (IL-17)

hAP-5814 50ug
EUR 400

ELISA kit for Human IL-17

KET6022-48T 48T
EUR 242.4
Description: Quantitative sandwich ELISA for measuring Human IL-17 in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human IL-17

KET6022-5platesof96wells 5 plates of 96 wells
EUR 1292.4
Description: Quantitative sandwich ELISA for measuring Human IL-17 in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human IL-17

KET6022-96T 96T
EUR 346.8
Description: Quantitative sandwich ELISA for measuring Human IL-17 in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Human IL-17 ELISA kit (4X96T)

LF-EK50202 4×96T
EUR 2641.2

Human IL-17 protein, His Tag

PRP100287-100ug 100 μg
EUR 779
Description: Human IL-17 protein, His Tag, expressed in Baculovirus-Insect Cells

Human IL-17 protein, His Tag

PRP100287-1mg 1 mg
EUR 4959
Description: Human IL-17 protein, His Tag, expressed in Baculovirus-Insect Cells

Human IL-17 protein, His Tag

PRP100288-100ug 100 μg
EUR 779
Description: Human IL-17 protein, His Tag, expressed in Yeast

Human IL-17 protein, His Tag

PRP100288-1mg 1 mg
EUR 4959
Description: Human IL-17 protein, His Tag, expressed in Yeast

CymaxTM Human IL-17 ELISA Kit

LF-EK0295 1×96T
EUR 477.6

IL-17 Interleukin-17 Human Recombinant Protein, His Tag

PROTQ16552-2 Regular: 10ug
EUR 380.4
Description: Interleukin-17A Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 132 amino acids fragment (24-155) having a molecular weight of 19.62kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. ;The IL-17A His is purified by proprietary chromatographic techniques.

IL-17

EF014060 96 Tests
EUR 826.8

IL-17

E8ER1706-91 100ul
EUR 275
Description: Available in various conjugation types.

IL-17

E5-00007 1mg
EUR 700

IL-17

GWB-3B32E2 0.025 mg Ask for price

IL-17

MO15110 500 ug
EUR 1092

IL-17

PR27113 5 ug
EUR 229.2

IL-17

PR27113-B each
EUR 184.5

Human Interleukin 17A(IL-17A,IL-17) Elisa Kit

EK710278 96 Wells
EUR 0.78

Human Interleukin 17A (IL-17A/IL-17) ELISA Kit

EKC40888-48T 48T
EUR 535.99

Human Interleukin 17A (IL-17A/IL-17) ELISA Kit

EKC40888-5x96T 5x96T
EUR 3637.08

Human Interleukin 17A (IL-17A/IL-17) ELISA Kit

EKC40888-96T 96T
EUR 765.7

Human Interleukin 17A (IL-17A/IL-17) ELISA Kit

CSB-E12819h-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 17A (IL-17A/IL-17) in samples from serum, urine, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Interleukin 17A (IL-17A/IL-17) ELISA Kit

1-CSB-E12819h
  • Ask for price
  • Ask for price
  • Ask for price
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 17A (IL-17A/IL-17) in samples from serum, urine, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human IL-17 /IL-17A ELISA kit (High Sensitivity)

E22-HC170(H).48 48T
EUR 495

Human IL-17 /IL-17A ELISA kit (High Sensitivity)

E22-HC170(H).96 96T
EUR 595

Anti‐Human IL‐17A

E2790213 100ul
EUR 225
Description: Available in various conjugation types.

IL-17/IL-17A

E21-021 10ug
EUR 225
Description: Recombinant Human Interleukin-17A is produced by our E.coli expression system and the target gene encoding Ile20-Ala155 is expressed.

Rat Monoclonal anti-mouse IL-17 Receptor

mAP-0104 100ug
EUR 250

Human IL-17 RB Protein, Fc Tag

ILB-H5251 1mg
EUR 374.5
Description: Human IL-17 RB, Fc Tag (ILB-H5251) is expressed from human 293 cells (HEK293). It contains AA Arg 18 - Pro 292 (Accession # Q9NRM6-1).

EliKine™ Human IL-17 ELISA Kit

KTE6022-48T 48 T
EUR 189
Description: EliKine™ Human IL-17 ELISA Kit employs a two-site sandwich ELISA to quantitate Human IL-17.

EliKine™ Human IL-17 ELISA Kit

KTE6022-96T 96 T
EUR 289
Description: EliKine™ Human IL-17 ELISA Kit employs a two-site sandwich ELISA to quantitate Human IL-17.

OKRC00573-96W - IL-17 ELISA Kit (Human)

OKRC00573-96W 96Wells
EUR 525

Mouse Monoclonal IL-17 RA/IL-17 R Antibody (49M4D2)

TA337125 100 µg Ask for price

Mouse Monoclonal IL-17 RA/IL-17 R Antibody (49M5D9)

TA337127 100 µg Ask for price

Mouse Monoclonal IL-17 RA/IL-17 R Antibody (49M7C6)

TA337128 100 µg Ask for price

Human Interleukin-17,IL-17A ELISA Kit

ELA-E1700h 96 Tests
EUR 988.8

Human IL-17 RA&IL-17 RC Heterodimer Protein, Fc Tag&Fc Tag (MALS verified)

ILC-H5257 100ug
EUR 2749.9
Description: Human IL17RA&IL17RC Protein, Fc Tag&Fc Tag (ILC-H5257) is expressed from human 293 cells (HEK293). It contains AA Leu 33 - Trp 320 (IL-17RA) & Leu 21 - His 465 (IL-17RC) (Accession # Q96F46-1 (IL-17RA) & NP_703190.1 (IL-17RC)).

Polyclonal IL-17 Antibody

APR06508G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IL-17 . This antibody is tested and proven to work in the following applications:

Polyclonal IL-17 Antibody

APR06512G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IL-17 . This antibody is tested and proven to work in the following applications:

Bovine Interleukin 17(IL-17)

QY-E60069 96T
EUR 511.2

Fish Interleukin 17-IL-17

QY-E160090 96T
EUR 580

Genorise® Anti-canine IL-17 Polyclonal Antibody

GR105162 100 ug
EUR 438

IL-17 Peptide

4877P 0.05 mg
EUR 197.7
Description: (NT) IL-17 peptide

IL-17 Peptide

4887P 0.05 mg
EUR 197.7
Description: (IN) IL-17 peptide

Mouse IL-17

GWB-ED9F68 0.025 mg Ask for price

human anti-human IL-5 mAb

E4A09D05 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-2 mAb

E409C12-h100 100μL
EUR 395
Description: Available in various conjugation types.

human anti-human IL-4 mAb

E409C13-h100 100μL
EUR 395
Description: Available in various conjugation types.

human anti-human IL-5 mAb

E409C14-h100 100μL
EUR 395
Description: Available in various conjugation types.

human anti-human IL-8 mAb

E409C16-h100 100μL
EUR 395
Description: Available in various conjugation types.

Recombinant Human IL-17 Receptor A/IL-17RA/CD217 (C-Fc)

CI53-10ug 10ug
EUR 120
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human IL-17 Receptor A/IL-17RA/CD217 (C-Fc)

CI53-1mg 1mg
EUR 1094.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human IL-17 Receptor A/IL-17RA/CD217 (C-Fc)

CI53-500ug 500ug
EUR 850.8
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human IL-17 Receptor A/IL-17RA/CD217 (C-Fc)

CI53-50ug 50ug
EUR 242.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human IL-17 Receptor A/IL-17RA/CD217 (C-Fc)

AP76027 1mg
EUR 1319

human anti-human IL-1β mAb

E409C11-h100 100μL
EUR 395
Description: Available in various conjugation types.

human anti-human IL-10 mAb

E409C17-h100 100μL
EUR 395
Description: Available in various conjugation types.

human anti-human IL-12/IL-23 p40 mAb(3H2)

E4A09D33-3H2 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human IL-12/IL-23 p40 mAb(5N9)

E4A09D33-5N9 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human IL-12/IL-23 p40 mAb(1G11)

E4A09D33-1G11 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Human IL-17 RA / CD217 Protein, Fc Tag

ILA-H5257 1mg
EUR 1166.3
Description: Human IL-17 RA Protein, Fc Tag (ILA-H5257) is expressed from human 293 cells (HEK293). It contains AA Leu 33 - Trp 320 (Accession # Q96F46-1).

Human IL-17 RA / CD217 Protein, His Tag

ILA-H5222 1mg
EUR 299.6
Description: Human IL-17 RA, His Tag (ILA-H5222) is expressed from human 293 cells (HEK293). It contains AA Leu 33 - Trp 320 (Accession # Q96F46-1).

Human IL-17A(Interleukin 17 A) ELISA Kit

EKF57643-48T 48T
EUR 396.9

Human IL-17A(Interleukin 17 A) ELISA Kit

EKF57643-5x96T 5x96T
EUR 2693.25

Human IL-17A(Interleukin 17 A) ELISA Kit

EKF57643-96T 96T
EUR 567

Human IL-17 F(Interleukin 17F) ELISA Kit

EKF59467-48T 48T
EUR 396.9

Human IL-17 F(Interleukin 17F) ELISA Kit

EKF59467-5x96T 5x96T
EUR 2693.25

Human IL-17 F(Interleukin 17F) ELISA Kit

EKF59467-96T 96T
EUR 567

Human IL-17A(Interleukin 17 A) ELISA Kit

EH3267 96T
EUR 571.5
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml

OKRC00574-96W - Il-17 B ELISA Kit (Human)

OKRC00574-96W 96Wells
EUR 525

OKRC00575-96W - IL-17 RB ELISA Kit (Human)

OKRC00575-96W 96Wells
EUR 525

OKRC00576-96W - IL-17 E ELISA Kit (Human)

OKRC00576-96W 96Wells
EUR 525

OKRC00578-96W - IL-17 R ELISA Kit (Human)

OKRC00578-96W 96Wells
EUR 525

Human Interleukin-17 A (IL-17A) ELISA Kit

LF-EK60049 1×96T
EUR 948

Wild-type mice treated with a control antibody also showed that cells CD19⁺, CD21⁺, sIgG⁺ in the CNS during the peak of EAE severity of the disease and detected serum autoantibodies. In contrast, wild-type mice treated with anti-VLA4 exhibited reduce the level of serum autoantibodies compared to control wild type and KO mice EVA

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