Asthma is frequently characterized by airway inflammation rich in eosinophils. Airway eosinophilia associated with exacerbations of asthma and may play a part in airway remodeling. Eosinophil recruitment of blood flow depends on the circulation of eosinophils become activated, leading to the arrest on endothelium activated eosinophils, extravasation, and continued movement through the bronchial tissue by interaction with the extracellular matrix (ECM).
Circulating eosinophils can exist at different levels of activation, which includes a non-activated or pre-activated (sensitized or “primed”). Furthermore, the blood flow may be less pre-activated cells, such as eosinophils after being arrested in the endothelium or extravasated into the tissues. Increased expression, and in some cases, decreased expression of cell surface proteins, including CD44, CD4 5 , CD4 5 R0, CD48, CD137, neuropeptide S receptors, cytokine receptors, receptor Fc, and integrin (receptors mediate cell adhesion and migration by interacting with ligands on other cells or in the ECM), and the countries switched from integrin , or Fc receptors on blood eosinophils have been reported to correlate with aspects of asthma. A subset of these proteins have been reported to respond to the intervention, for example, with anti -interleukin (IL) – 5 .
How these surface proteins and activation state of eosinophils respond to other interventions, for example, with anti -iL-4 receptor alpha or anti – IL-13, not known. Eosinophils surface protein suggested to be a biomarker activation, in particular integrin , and a report on the correlation between the activation of eosinophils and asthma aspects described in this review. secondary activation of beta1 and beta2 integrin on circulating eosinophils correlated with decreased lung function, inflammation of the airways, or airway lumen eosinophils in non-severe asthma. correlation does not appear in severe asthma, possibly because of a higher level of pre-activated extravasation of eosinophils in more severe disease.
Bronchoalveolar lavage (BAL) eosinophils have been very active integrin and other changes in the surface protein compared with blood eosinophils. The state of activation of eosinophils in the lung tissue, although it may be very important in asthma, is largely unknown. However, some recent articles, particularly in rats but mostly on the Human cells, suggesting that tissue eosinophils may have a surface phenotype (s) different from the sputum or BAL eosinophils.
Eosinophil Activation Status in Separate Compartments and Association with Asthma.
Selumetinib Inhibits Metastatic Melanoma Mouse Liver via EMT gene-targeted eradication.
We investigated the effects of mitogen-activated protein therapy (MEK) inhibitor, selumetinib, in the model of liver metastasis melanoma and study the mechanisms that might work.
melanoma cell lines exposed to selumetinib under different experimental conditions. We established a mouse model of liver metastasis and mice treated orally with vehicle or selumetinib and progress of metastasis were evaluated.
Description: A sandwich ELISA for quantitative measurement of Human Galectin 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Human Galectin 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Human Galectin 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: This monoclonal antibody is for studies of antigen expression in cells and tissue sections using immunocytochemistry and immunoprecipitation
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Galectin-1 in samples from serum, plasma, tissue homogenates and other biological fluids.
Description: Lectins, of either plant or animal origin, are carbohydrate binding proteins that interact with glycoprotein and glycolipids on the surface of animal cells. The Galectins are lectins that recognize and interact with β-galactoside moieties. Galectin-1 is an animal lectin that has been shown to interact with CD3, CD4, and CD45. It induces apoptosis of activated T-cells and T-leukemia cell lines and inhibits the protein phosphatase activity of CD45. Recombinant human Galectin-1 is a 14.5 kDa protein containing 134 amino acid residues.
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Galectin 1 (GAL1) in serum, plasma and other biological fluids.
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Galectin 1 (GAL1) in serum, plasma and other biological fluids.
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Galectin 1 (GAL1) in serum, plasma and other biological fluids.
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Galectin 1 (GAL1) in serum, plasma and other biological fluids.
Description: Quantitativesandwich ELISA kit for measuring Human Galectin-1 (LGALS1) in samples from serum, plasma, tissue homogenates, cell lysates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.
Description: Quantitativesandwich ELISA kit for measuring Human Galectin-1(LGALS1) in samples from serum, plasma, tissue homogenates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.
Description: A competitive ELISA for quantitative measurement of Human Galectin-1(LGALS1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Human Galectin-1(LGALS1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Human Galectin-1(LGALS1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Human Galectin-1 (Gal-1) Antibody (Biotin Conjugate)
Description: A sandwich quantitative ELISA assay kit for detection of Human Galectin 1 (GAL1) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Human Galectin 1 (GAL1) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Galectin 1 (GAL1) in serum, plasma, tissue homogenates and other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Galectin 1 (GAL1) in serum, plasma, tissue homogenates and other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Galectin 1 (GAL1) in serum, plasma, tissue homogenates and other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Galectin 1 (GAL1) in serum, plasma, tissue homogenates and other biological fluids.
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Galectin 1 (GAL1) in samples from serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species.
Description: Galectin-1 is a protein that in humans is encoded by the LGALS1 gene. The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Galectin-1 may act as an autocrine negative growth factor that regulates cell proliferation. Galectin-1 expression in Hodgkin Lymphoma has also been shown to mediate immunosuppression of CD8+ T-cells. It is thought to play a role in creatingimmune tolerance in pregnancy. It has been found that Galectin-1-mediated production of IL6 may assist in augmenting the innate immune response against NiV. Galectin-1 may also be a significant factor that augments the efficiency of the HIV-1 infection process.
Description: Galectin-1 is a protein that in humans is encoded by the LGALS1 gene. The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Galectin-1 may act as an autocrine negative growth factor that regulates cell proliferation. Galectin-1 expression in Hodgkin Lymphoma has also been shown to mediate immunosuppression of CD8+ T-cells. It is thought to play a role in creating immune tolerance in pregnancy. It has been found that Galectin-1-mediated production of IL6 may assist in augmenting the innate immune response against NiV. Galectin-1 may also be a significant factor that augments the efficiency of the HIV-1 infection process.
Description: Galectin-1 is a protein that in humans is encoded by the LGALS1 gene. The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Galectin-1 may act as an autocrine negative growth factor that regulates cell proliferation. Galectin-1 expression in Hodgkin Lymphoma has also been shown to mediate immunosuppression of CD8+ T-cells. It is thought to play a role in creating immune tolerance in pregnancy. It has been found that Galectin-1-mediated production of IL6 may assist in augmenting the innate immune response against NiV. Galectin-1 may also be a significant factor that augments the efficiency of the HIV-1 infection process.
Description: Quantitative sandwich ELISA for measuring Human Galectin-1 (LGALS1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
Description: Quantitative sandwich ELISA for measuring Human Galectin-1 (LGALS1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
Description: Quantitative sandwich ELISA for measuring Human Galectin-1 (LGALS1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
Description: A sandwich ELISA kit for detection of Galectin 1 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.
Description: LGALS1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 135 amino acids and having a molecular mass of 14.7kDa.;The LGALS1 is purified by proprietary chromatographic techniques.
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Galectin-1 . This antibody is tested and proven to work in the following applications:
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Galectin-1 . This antibody is tested and proven to work in the following applications:
Description: A polyclonal antibody for detection of Galectin-1 from Human, Rat. This Galectin-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Galectin-1 at AA rangle: 10-90
Description: A polyclonal antibody for detection of Galectin-1 from Human, Rat. This Galectin-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Galectin-1 at AA rangle: 10-90
Description: A polyclonal antibody for detection of Galectin-1 from Human, Rat. This Galectin-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Galectin-1 at AA rangle: 10-90
Description: A polyclonal antibody for detection of Galectin-1 from Human, Mouse, Rat. This Galectin-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human Galectin-1 protein at amino acid sequence of 30-80
Description: A polyclonal antibody for detection of Galectin-1 from Human, Mouse, Rat. This Galectin-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human Galectin-1 protein at amino acid sequence of 30-80
Description: A polyclonal antibody for detection of Galectin-1 from Human, Mouse, Rat. This Galectin-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human Galectin-1 protein at amino acid sequence of 30-80
Description: A Rabbit Polyclonal antibody against Galectin-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA
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The growth inhibition was observed in melanoma cells as a consequence of G1 phase cell cycle arrest and subsequent induction of apoptosis in a dose-and time-dependent. Mice with established liver metastases treated with selumetinib exhibited tumor progression was significantly less than vehicle-treated mice. c-Myc expression in the liver metastasis was suppressed by selumetinib. In addition, oral treatment with selumetinib modulated the expression of epithelial-to-mesenchymal transition- and genes related to metastasis, including integrin alpha – 5 ( ITGA 5 ), serrated 1 (JAG1), zinc finger E-box binding homeobox 1 (ZEB1), NOTCH, and serpin peptidase inhibitor clade E (SERPINE1).
