Triptolide inhibits angiogenesis in microvascular endothelial cells through regulation of miR-92a.

Triptolide inhibits angiogenesis in microvascular endothelial cells through regulation of miR-92a.

Atherosclerosis is a common chronic inflammatory disease in which angiogenesis is involved. Here we established in vitro cell model of angiogenesis was made by Human dermal microvascular endothelial cells (HMEC-1) and work to investigate the role of triptolide (TPL) in this model. To induce angiogenesis, HMEC-1 cells were cultured on Matrigel-conditioned medium.

The ratio of the core tube to be detected. To evaluate angiogenesis, Western blot test is done to detect endothelial nitric oxide synthase (eNOS), vascular endothelial growth factor receptor-2 (VEGFR2) and VEGF. Cell counting kit-8 is used to estimate the survival of HMEC-1 cells. microRNA (mir) -92a analyzed by qRT-PCR. Targeting the relationship between the integrin subunit alpha 5 (ITGA 5 ) and miR-92A verified by luciferase activity assay. Effects of ITGA 5 on the signal transducer (ERK, PI3K, and Akt) in the form of phosphorylated assessed using Western blot method.

Once stimulated by TPL, LY294002 and PD980 5 9, changes in phosphorylation of signal transducer was evaluated by Western blot test. The ratio of the core tube and angiogenesis related factors increased with the delay time of culture. TPL decreased the expression of angiogenesis factors. Furthermore, miR-92A is regulated by miR-92A TPL and silent deregulated angiogenesis factor. Additionally, WMT declined ITGA 5 which proved to be the target of miR-92A. ITGA 5 the excess resulted in an abundance of angiogenesis factor while ITGA 5 silence led to the opposite result. Meanwhile, ITGA 5 the excess increases the phosphorylation of ERK, PI3K and AKT while ITGA 5 quietly reversed the trend. TPL (as anti -angiogenesis agent) suppressed angiogenesis by upregulating miR-92A, and miR-92A-mediated down-regulation of ITGA 5 block signal transduction of ERK and PI3K pathways / AKT.

Triptolide inhibits angiogenesis in microvascular endothelial cells through regulation of miR-92a.
Triptolide inhibits angiogenesis in microvascular endothelial cells through regulation of miR-92a.

Overlapping pattern of expression and function of the three paralogous P5B ATPase in Caenorhabditis elegans.

ATPase which is present in the genome of a variety of unicellular and multicellular eukaryotes, suggesting that they have an ancient origin, and that they are important for cellular fitness. Inactivation ATP13A2, one of the four Human P 5 B ATPase, leading to early-onset Parkinson’s disease (Kufor-Rakeb Syndrome). The presence in the pocket motif PPALP invariant substrate interaction suspected transmembrane segment M4 showed that all P 5 ATPase B may have the same transport specificity; However, the identity of the transport substrate (s) is still unknown.

Nematodes of the genus Caenorhabditis has three paralogous P 5 ATPase gene B, catp- 5 , CATP CATP-6 and 7, which may be derived from a single ancestral gene around the time of the origin of clade Caenorhabditid. By using the CRISPR / Cas9, we have systematically investigated the expression patterns, subcellular localization and biological function of each P 5 B ATPase of C. elegans.

Anti-CD163

DB-045-0.1 100 μl
EUR 254.4
Description: rabbit monospecific clonal antibodies for ihc-p application; concentrated

Anti-CD163

DB-045-0.2 200 μl
EUR 357.6
Description: rabbit monospecific clonal antibodies for ihc-p application; concentrated

Anti-CD163

DB-045-0.5 500 μl
EUR 460.8
Description: rabbit monospecific clonal antibodies for ihc-p application; concentrated

Anti-CD163

DB-045-1 1 ml
EUR 735.6
Description: rabbit monospecific clonal antibodies for ihc-p application; concentrated

Anti-CD163

DB-045-RTU-15 15 ml
EUR 424.8
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-CD163

DB-045-RTU-7 7 ml
EUR 277.2
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-CD163

DB045RTU-15 15 ml
EUR 424.8
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-CD163

DB045RTU-7 7 ml
EUR 277.2
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Mouse Cluster Of Differentiation (CD163) ELISA Kit

DLR-CD163-Mu-48T 48T
EUR 609.6
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Cluster Of Differentiation (CD163) in samples from serum, plasma or other biological fluids.

Mouse Cluster Of Differentiation (CD163) ELISA Kit

DLR-CD163-Mu-96T 96T
EUR 793.2
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Cluster Of Differentiation (CD163) in samples from serum, plasma or other biological fluids.

Rat Cluster Of Differentiation (CD163) ELISA Kit

DLR-CD163-Ra-48T 48T
EUR 609.6
Description: A sandwich quantitative ELISA assay kit for detection of Rat Cluster Of Differentiation (CD163) in samples from serum, plasma, tissue homogenates or other biological fluids.

Rat Cluster Of Differentiation (CD163) ELISA Kit

DLR-CD163-Ra-96T 96T
EUR 793.2
Description: A sandwich quantitative ELISA assay kit for detection of Rat Cluster Of Differentiation (CD163) in samples from serum, plasma, tissue homogenates or other biological fluids.

Mouse Cluster Of Differentiation (CD163) ELISA Kit

RD-CD163-Mu-48Tests 48 Tests
EUR 613.2

Mouse Cluster Of Differentiation (CD163) ELISA Kit

RD-CD163-Mu-96Tests 96 Tests
EUR 850.8

Rat Cluster Of Differentiation (CD163) ELISA Kit

RD-CD163-Ra-48Tests 48 Tests
EUR 613.2

Rat Cluster Of Differentiation (CD163) ELISA Kit

RD-CD163-Ra-96Tests 96 Tests
EUR 850.8

Mouse Cluster Of Differentiation (CD163) ELISA Kit

RDR-CD163-Mu-48Tests 48 Tests
EUR 640.8

Mouse Cluster Of Differentiation (CD163) ELISA Kit

RDR-CD163-Mu-96Tests 96 Tests
EUR 890.4

Rat Cluster Of Differentiation (CD163) ELISA Kit

RDR-CD163-Ra-48Tests 48 Tests
EUR 640.8

Rat Cluster Of Differentiation (CD163) ELISA Kit

RDR-CD163-Ra-96Tests 96 Tests
EUR 890.4

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 418.8

Anti-CD163 Antibody

A00812-1 100ug/vial
EUR 400.8

Anti-CD163 Antibody

PA1874 100ug/vial
EUR 352.8

Anti-CD163 Antibody

PA1874-1 100ug/vial
EUR 400.8

Anti-CD163 antibody

STJ110681 100 µl
EUR 332.4
Description: The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Anti-CD163 Antibody

STJ500423 100 µg
EUR 571.2

Anti-CD163 Antibody

STJ500424 100 µg
EUR 571.2

Anti-CD163 antibody

STJ160082 1 mL C
EUR 1129.2

Anti-CD163 antibody

STJ16100302 100 µg
EUR 864

Anti-CD163 antibody

STJ16100324 1 mL
EUR 1174.8

Anti-CD163 antibody

STJ180301 0.1 ml
EUR 258

Anti-CD163 antibody

STJ190009 200 µl
EUR 236.4
Description: Unconjugated Mouse monoclonal to CD163 (AS1A1)

Anti-Hu CD163 Purified

11-645-C025 0.025 mg
EUR 118.8

Anti-Hu CD163 Purified

11-645-C100 0.1 mg
EUR 189.6

Anti-CD163/M130 Antibody

A00812 100ul
EUR 476.4
Description: Rabbit IgG polyclonal antibody for Scavenger receptor cysteine-rich type 1 protein M130 (CD163) detection.tested for IF, IHC, WB in Human, Mouse, Rat. Various direct flourescent conjugates are available for FCM upon request. Please contact us for details.

Anti-Hu CD163 APC

1A-645-T025 25 tests
EUR 168

Anti-Hu CD163 APC

1A-645-T100 100 tests
EUR 288

Anti-Hu CD163 PE

1P-645-T025 25 tests
EUR 168

Anti-Hu CD163 PE

1P-645-T100 100 tests
EUR 288

Anti-CD163/M130 antibody

PAab09771 100 ug
EUR 426

anti- CD163/M130 Antibody

FNab09771 100µg
EUR 658.5
Description: Antibody raised against CD163/M130 

Anti-CD163 Antibody BIOTIN

STJ500425 100 µg
EUR 703.2

Anti-CD163 Antibody FITC

STJ500426 100 µg
EUR 703.2

Anti-CD163 Antibody BIOTIN

STJ500427 100 µg
EUR 703.2

Anti-CD163 Antibody FITC

STJ500428 100 µg
EUR 703.2

human CD163 antigen,CD163 LISA kit

201-12-0247 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human CD163 antigen(CD163)ISA kit

GA-E0263HM-48T 48T
EUR 346.8

Human CD163 antigen(CD163)ISA kit

GA-E0263HM-96T 96T
EUR 559.2

Human CD163 antigen(CD163)ISA kit

QY-E05066 96T
EUR 433.2

Mouse Anti Human Cd163 Monoclonal Antibody

CABT-47162MH 25 µg
EUR 446.4

Mouse Anti Human Cd163 Monoclonal Antibody

CABT-47163MH 0.2 mg
EUR 1057.2

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 336

Polyclonal Goat anti-GST μ-form

GST-ANTI-2 50 uL
EUR 336

Polyclonal Goat anti-GST p-form

GST-ANTI-3 50 uL
EUR 336

Anti-CD163 Rabbit Monoclonal Antibody

M00812 100ug/vial
EUR 476.4
Description: Rabbit Monoclonal CD163 Antibody. Validated in IP, WB and tested in Human.

Anti-Hu CD163 PE-Cy7

T7-645-T025 25 tests
EUR 184.8

Anti-Hu CD163 PE-Cy7

T7-645-T100 100 tests
EUR 321.6

Anti-Hu CD163 PerCP-Cy5.5

T9-645-T025 25 tests
EUR 235.2

Anti-Hu CD163 PerCP-Cy5.5

T9-645-T100 100 tests
EUR 422.4

Purified Anti-human CD163 Antibody *GHI/61*

11630000 100 ug
EUR 365

APC Anti-human CD163 Antibody *GHI/61*

116301B0 25 tests
EUR 383

APC Anti-human CD163 Antibody *GHI/61*

116301B1 100 tests
EUR 995

APC Anti-human CD163 Antibody *GHI/61*

116301B2 500 tests
EUR 2984

FITC Anti-human CD163 Antibody *GHI/61*

116301G0 100 tests
EUR 547

FITC Anti-human CD163 Antibody *GHI/61*

116301G1 500 tests
EUR 2051

TRITC Anti-human CD163 Antibody *GHI/61*

116301H0 100 tests
EUR 547

TRITC Anti-human CD163 Antibody *GHI/61*

116301H1 500 tests
EUR 2051

PacBlue Anti-human CD163 Antibody *GHI/61*

116301I0 100 tests
EUR 547

PacBlue Anti-human CD163 Antibody *GHI/61*

116301I1 500 tests
EUR 2051

PacOrange Anti-human CD163 Antibody *GHI/61*

116301J0 100 tests
EUR 547

PacOrange Anti-human CD163 Antibody *GHI/61*

116301J1 500 tests
EUR 2051

PE Anti-human CD163 Antibody *GHI/61*

116301K0 25 tests
EUR 383

PE Anti-human CD163 Antibody *GHI/61*

116301K1 100 tests
EUR 995

PE Anti-human CD163 Antibody *GHI/61*

116301K2 500 tests
EUR 2984

PerCP Anti-human CD163 Antibody *GHI/61*

116301S0 25 tests
EUR 383

PerCP Anti-human CD163 Antibody *GHI/61*

116301S1 100 tests
EUR 995

PerCP Anti-human CD163 Antibody *GHI/61*

116301S2 500 tests
EUR 2984

Porcine CD163 antigen,CD163 LISA kit

GA-E0045PC-48T 48T
EUR 436.8

Porcine CD163 antigen,CD163 LISA kit

GA-E0045PC-96T 96T
EUR 708

Canine CD163 antigen(CD163 LISA kit

GA-E0062CN-48T 48T
EUR 482.4

Canine CD163 antigen(CD163 LISA kit

GA-E0062CN-96T 96T
EUR 820.8

CD163 Antibody

49553-100ul 100ul
EUR 399.6

CD163 Antibody

49553-50ul 50ul
EUR 286.8

CD163 Antibody

37157-100ul 100ul
EUR 302.4

CD163 antibody

10R-6496 100 ug
EUR 243.6
Description: Mouse monoclonal CD163 antibody

CD163 antibody

10R-CD163aRT 250 ug
EUR 859.2
Description: Mouse monoclonal CD163 antibody

CD163 Antibody

ABD8235 100 ug
EUR 525.6

CD163 Antibody

20-abx242956
  • EUR 560.40
  • EUR 393.60
  • 100 ul
  • 50 ul

CD163 siRNA

20-abx910930
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

CD163 siRNA

20-abx910931
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

CD163 Antibody

1-CSB-PA801238LA01HU
  • EUR 380.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against CD163. Recognizes CD163 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IF; Recommended dilution: IF:1:50-1:200

Cd163 Antibody

1-CSB-PA650452LA01MO
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Cd163. Recognizes Cd163 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB; Recommended dilution: WB:1:500-1:2000

CD163 Antibody

1-CSB-PA969205
  • EUR 380.40
  • EUR 292.80
  • 100ul
  • 50ul
Description: A polyclonal antibody against CD163. Recognizes CD163 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:2000, IHC:1:25-1:100

CD163 Antibody

DF8235 200ul
EUR 420

CD163 Antibody

R30973 100 ug
EUR 419

CD163 Antibody

R30974 100 ug
EUR 419

CD163 Antibody

RQ4259 100 ug
EUR 419

CD163 Antibody

F50316-0.08ML 0.08 ml
EUR 165

CD163 Antibody

F50316-0.4ML 0.4 ml
EUR 379

CD163 Antibody

V8227-100UG 100 ug
EUR 499
Description: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.

CD163 Antibody

V8227-20UG 20 ug
EUR 219
Description: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.

CD163 Antibody

V8227SAF-100UG 100 ug
EUR 499
Description: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.

CD163 Antibody

V8415-100UG 100 ug
EUR 499
Description: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.

CD163 Antibody

V8415-20UG 20 ug
EUR 219
Description: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.

CD163 Antibody

V8415SAF-100UG 100 ug
EUR 499
Description: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.

CD163 Antibody

V8757-100UG 100 ug
EUR 499
Description: CD163 is a type I membrane protein, and is a member of the hemoglobin scavenger receptor cystein-rich superfamily. The protein is involved in the clearance of hemoglobin-haptoglobin complexes and is considered to have anti-inflammatory functions. CD163 expression is restricted to the monocytic/macrophage lineage. It is expressed by all circulating monocytes and by a majority of tissue macrophages, such as splenic dendrocytes, alveolar macrophages and Kupffer cells of the liver. It is not present in macrophages in the mantle zone and some of the germinal center cells in lymph follicles, nor in Langerhans cells and interdigitating reticulum cells. In tumor tissues, CD163 is found in almost all cases of acute myeloid leukemia with monocytoid differentiation and in the majority of cases of histiocytic sarcoma, littoral cell angioma, Rosai-Dorfman disease, Langerhans cell histiocytosis and typical and atypical fibrous histiocytoma. It is also expressed in some cases of dermatofibrosarcoma protuberans. CD163 can be used to detect cells of monocytic and histiocyte lineage in neoplastic and reactive lesions. It has been shown to be more sensitive than CD68 for the detection of macrophages and monocytic cells. It covers a similar, but not identical, spectrum of cells as CD68.

CD163 Antibody

V8757-20UG 20 ug
EUR 219
Description: CD163 is a type I membrane protein, and is a member of the hemoglobin scavenger receptor cystein-rich superfamily. The protein is involved in the clearance of hemoglobin-haptoglobin complexes and is considered to have anti-inflammatory functions. CD163 expression is restricted to the monocytic/macrophage lineage. It is expressed by all circulating monocytes and by a majority of tissue macrophages, such as splenic dendrocytes, alveolar macrophages and Kupffer cells of the liver. It is not present in macrophages in the mantle zone and some of the germinal center cells in lymph follicles, nor in Langerhans cells and interdigitating reticulum cells. In tumor tissues, CD163 is found in almost all cases of acute myeloid leukemia with monocytoid differentiation and in the majority of cases of histiocytic sarcoma, littoral cell angioma, Rosai-Dorfman disease, Langerhans cell histiocytosis and typical and atypical fibrous histiocytoma. It is also expressed in some cases of dermatofibrosarcoma protuberans. CD163 can be used to detect cells of monocytic and histiocyte lineage in neoplastic and reactive lesions. It has been shown to be more sensitive than CD68 for the detection of macrophages and monocytic cells. It covers a similar, but not identical, spectrum of cells as CD68.

CD163 Antibody

V8757SAF-100UG 100 ug
EUR 499
Description: CD163 is a type I membrane protein, and is a member of the hemoglobin scavenger receptor cystein-rich superfamily. The protein is involved in the clearance of hemoglobin-haptoglobin complexes and is considered to have anti-inflammatory functions. CD163 expression is restricted to the monocytic/macrophage lineage. It is expressed by all circulating monocytes and by a majority of tissue macrophages, such as splenic dendrocytes, alveolar macrophages and Kupffer cells of the liver. It is not present in macrophages in the mantle zone and some of the germinal center cells in lymph follicles, nor in Langerhans cells and interdigitating reticulum cells. In tumor tissues, CD163 is found in almost all cases of acute myeloid leukemia with monocytoid differentiation and in the majority of cases of histiocytic sarcoma, littoral cell angioma, Rosai-Dorfman disease, Langerhans cell histiocytosis and typical and atypical fibrous histiocytoma. It is also expressed in some cases of dermatofibrosarcoma protuberans. CD163 can be used to detect cells of monocytic and histiocyte lineage in neoplastic and reactive lesions. It has been shown to be more sensitive than CD68 for the detection of macrophages and monocytic cells. It covers a similar, but not identical, spectrum of cells as CD68.

CD163 Antibody

V3937-100UG 100 ug
EUR 499
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.

CD163 Antibody

V3937-20UG 20 ug
EUR 219
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.

CD163 Antibody

V3937SAF-100UG 100 ug
EUR 499
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.

CD163 Antibody

V7470-100UG 100 ug
EUR 499
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.

CD163 Antibody

V7470-20UG 20 ug
EUR 219
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.

CD163 Antibody

V7470IHC-7ML 7 ml
EUR 499
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.

CD163 Antibody

V7470SAF-100UG 100 ug
EUR 499
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.

Human CD163 shRNA Plasmid

20-abx956176
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Human CD163 ELISA Kit

LF-EK50890 1×96T
EUR 777.6

Human CD163 ELISA Kit

ELA-E1726h 96 Tests
EUR 988.8

Mouse Anti Rat Cd163 Monoclonal Antibody

DMABT-47170MR 0.25 mg
EUR 889.2

Mouse Anti Rat Cd163 Monoclonal Antibody

DMABT-47171MR 0.1 mg
EUR 670.8

Anti-Human CD163 DyLight® 488 conjugated Antibody

A00812-Dyl488 100ug/vial
EUR 412.8

Anti-Human CD163 DyLight® 550 conjugated Antibody

A00812-Dyl550 100ug/vial
EUR 412.8

Mouse Anti-Human CD163 monoclonal antibody, clone JID274

CABT-L2938-100uL500uL 100 uL, 500 uL
EUR 602.4

APC/Cy7 Anti-human CD163 Antibody *GHI/61*

116301C0 25 tests
EUR 429

APC/Cy7 Anti-human CD163 Antibody *GHI/61*

116301C1 100 tests
EUR 1117

APC/Cy7 Anti-human CD163 Antibody *GHI/61*

116301C2 500 tests
EUR 3351

PE/Cy5 Anti-human CD163 Antibody *GHI/61*

116301L0 25 tests
EUR 429

PE/Cy5 Anti-human CD163 Antibody *GHI/61*

116301L1 100 tests
EUR 1117

PE/Cy5 Anti-human CD163 Antibody *GHI/61*

116301L2 500 tests
EUR 3351

PE/Cy7 Anti-human CD163 Antibody *GHI/61*

116301M0 25 tests
EUR 429

PE/Cy7 Anti-human CD163 Antibody *GHI/61*

116301M1 100 tests
EUR 1117

PE/Cy7 Anti-human CD163 Antibody *GHI/61*

116301M2 500 tests
EUR 3351

PerCP/Cy5.5 Anti-human CD163 Antibody *GHI/61*

116301T0 25 tests
EUR 429

PerCP/Cy5.5 Anti-human CD163 Antibody *GHI/61*

116301T1 100 tests
EUR 1117

PerCP/Cy5.5 Anti-human CD163 Antibody *GHI/61*

116301T2 500 tests
EUR 3351

Human CellExp? CD163, Human recombinant

9226-10
EUR 366

Human CellExp? CD163, Human recombinant

9226-50
EUR 927.6

iFluor® 350 Anti-human CD163 Antibody *GHI/61*

11630010 100 tests
EUR 547

iFluor® 350 Anti-human CD163 Antibody *GHI/61*

11630011 500 tests
EUR 2051

iFluor® 405 Anti-human CD163 Antibody *GHI/61*

11630020 100 tests
EUR 547

iFluor® 405 Anti-human CD163 Antibody *GHI/61*

11630021 500 tests
EUR 2051

iFluor® 430 Anti-human CD163 Antibody *GHI/61*

11630030 100 tests
EUR 547

iFluor® 430 Anti-human CD163 Antibody *GHI/61*

11630031 500 tests
EUR 2051

iFluor® 450 Anti-human CD163 Antibody *GHI/61*

11630040 100 tests
EUR 547

iFluor® 450 Anti-human CD163 Antibody *GHI/61*

11630041 500 tests
EUR 2051

iFluor® 488 Anti-human CD163 Antibody *GHI/61*

11630050 100 tests
EUR 547

iFluor® 488 Anti-human CD163 Antibody *GHI/61*

11630051 500 tests
EUR 2051

iFluor® 514 Anti-human CD163 Antibody *GHI/61*

11630060 100 tests
EUR 547

iFluor® 514 Anti-human CD163 Antibody *GHI/61*

11630061 500 tests
EUR 2051

iFluor® 532 Anti-human CD163 Antibody *GHI/61*

11630070 100 tests
EUR 547

iFluor® 532 Anti-human CD163 Antibody *GHI/61*

11630071 500 tests
EUR 2051

iFluor® 546 Anti-human CD163 Antibody *GHI/61*

11630080 100 tests
EUR 547

iFluor® 546 Anti-human CD163 Antibody *GHI/61*

11630081 500 tests
EUR 2051

iFluor® 555 Anti-human CD163 Antibody *GHI/61*

11630090 100 tests
EUR 547

iFluor® 555 Anti-human CD163 Antibody *GHI/61*

11630091 500 tests
EUR 2051

iFluor® 560 Anti-human CD163 Antibody *GHI/61*

116300A0 100 tests
EUR 547

iFluor® 560 Anti-human CD163 Antibody *GHI/61*

116300A1 500 tests
EUR 2051

iFluor® 568 Anti-human CD163 Antibody *GHI/61*

116300B0 100 tests
EUR 547

iFluor® 568 Anti-human CD163 Antibody *GHI/61*

116300B1 500 tests
EUR 2051

iFluor® 594 Anti-human CD163 Antibody *GHI/61*

116300C0 100 tests
EUR 547

iFluor® 594 Anti-human CD163 Antibody *GHI/61*

116300C1 500 tests
EUR 2051

iFluor® 610 Anti-human CD163 Antibody *GHI/61*

116300D0 100 tests
EUR 547

iFluor® 610 Anti-human CD163 Antibody *GHI/61*

116300D1 500 tests
EUR 2051

iFluor® 633 Anti-human CD163 Antibody *GHI/61*

116300E0 100 tests
EUR 547

iFluor® 633 Anti-human CD163 Antibody *GHI/61*

116300E1 500 tests
EUR 2051

iFluor® 647 Anti-human CD163 Antibody *GHI/61*

116300F0 100 tests
EUR 547

iFluor® 647 Anti-human CD163 Antibody *GHI/61*

116300F1 500 tests
EUR 2051

We found that each gene has a unique expression pattern, and that some of the tissue revealed more than one P 5 B. In some networks where they are overlapping expression patterns, which differ P 5 B is targeted to different subcellular compartments (eg, early endosomes vs plasma membrane), whereas in other tissues they localize to the same compartment (plasma membrane). We observed lysosomes co-localization between CATP-6 :: GFP and LMP-1 :: RFP in transgenic animals; However, this is an artifact of the tag LMP-1 protein, as anti -LMP-1 anti original body protein staining revealed that LMP-1 and CATP-6:: GFP occupy different compartments.

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